关键词:
VENOUS OXYGEN-SATURATION
FLUID RESPONSIVENESS
INTENSIVE-CARE
HEMODYNAMIC MANAGEMENT
CONTROLLED-TRIAL
DIFFERENCE
THERAPY
SURGERY
HYPERCARBIA
INDICATOR
摘要:
The aim of this study was to compare stroke volume (SVI) to cardiac index (CI) guided resuscitation in a bleeding-resuscitation experiment. Twenty six pigs were randomized and bled in both groups till baseline SVI (T-bsl) dropped by 50% (T-0), followed by resuscitation with crystalloid solution until initial SVI or CI was reached (T-4). Similar amount of blood was shed but animals received significantly less fluid in the CI-group as in the SVI-group: median = 900 (interquartile range: 850-1780) versus 1965 (1584-2165) mL, p - 0.02, respectively. In the SVI-group all variables returned to their baseline values, but in the CI-group animals remained underresuscitated as indicated by SVI, heart rate (HR) and stroke volume variation (SVV), and central venous oxygen saturation (ScvO2) at T-4 as compared to T-bsl: SVI = 23.8 +/- 5.9 versus 31.4 +/- 4.7 mL, HR: 117 +/- 35 versus 89 +/- 11/min SVV: 17.4 +/- 7.6 versus 11.5 +/- 5.3%, and ScvO2 : 64.1 +/- 11.6 versus 79.2 +/- 8.1%, p < 0.05, respectively. Our results indicate that CI-based goal-directed resuscitationmay result in residual hypovolaemia, as bleeding caused stress induced tachycardia "normalizes" CI, without restoring adequate SVI. As the SVI-guided approach normalized most hemodynamic variables, we recommend using SVI instead of CI as the primary goal of resuscitation during acute bleeding.