关键词： 神经生理学   疼痛   综述  

关键词： Hippocampus   Aging   Synaptic vesicles   Neurophysiology  

摘要： Synaptic vesicle populations were quantified in Schaffer-commissural synapses which terminate on CA1 pyramidal cell apical dendrites, in aging and young-mature rats. Vesicles were found to be reduced with age, and this effect was most pronounced in the oldest animals (e.g., 28 months) within the aged group. Numerical density of synaptic vesicles in aged rat hippocampus was reduced whether expressed as vesicles per terminal, vesicles per μ² of terminal, or vesicles per μ² of terminal corrected for shrinkage or swelling as assessed by mitochondrial cross-sectional diameters. Counted synaptic terminal areas were not significantly different in the aged animals, although a trend toward reduced terminal size with aging was seen. The latter observation apparently rules out increased terminal swelling in aged rat synapses as a basis for reduced vesicle density. In some rats, neurophysiological studies were concomitantly performed. A significant correlation was found between the amplitude of the monosynaptic population spike after 20 min of 4 Hz stimulation of the Schaffer-commissural fibers and synaptic vesicle populations in terminals of these stimulated pathways. However, because of a low n this result must be viewed as preliminary.

关键词： 脊髓   脑干   神经生理学   神经元   传出   中缝核   猫  

关键词： 神经生理学   脑电图   电诊断图   Menkes   视网膜电图   眼科检查  

摘要： 1962年Menkes等首先描述一种少见的性连代谢疾病,表现为婴儿早期生长迟缓,惊厥和低温。由于有典型的畸形头发,又称之为“卷发病”(kinky hair dis)。后Dankes等发现患者有血清铜和血浆铜蓝蛋白的缺乏,以及铜通过小肠表皮的缺陷,但是胃肠道外给予足够增加血清铜浓度的铜剂并不能改变本病的临床过程。

关键词： 脑研究   神经生理学   神经元   神经组织   神经系统电生理学   神经解剖学   过氧化酶   递质   神经药理学   轴突运输   同位素标记   神经微管  

摘要： 一、前言:各学科间的相互渗透促进了脑研究的发展:近年以来,神经生理学的发展,同其他学科一样,有一个显著的趋势,就是各学科之间的相互渗透。这种趋势,不自今日始,从来就是这样,不过最近十余年来变得更加显著罢了。这表现在许多方面,首先是研究课题的多样性。如果你任意拿起一本关于神经生理学的期刊来看,你会发现其中论文题目是五花八门,使你觉得很多篇文章往往牵涉到很多邻近

关键词： 神经生理学   生物化学   综述  

关键词： Binaural hearing   Acoustic noise   Neurophysiology   Psychophysics  

摘要： In this study the response characteristics of inferior colliculus neurons were investigated. Three types of binaural, high‐frequency stimuli were used: (1) two‐tone complexes, (2) noise bands, and (3) transients. For two‐tone complexes, frequency and depth of modulation were varied. Continuous, binaural, low‐pass, uncorrelated noise was used to mask the difference tone. For high‐frequency transients the low‐pass masker had either a 3 or 5‐kHz upper cutoff frequency. Neurons were found which responded differentially to interaural‐time differences for one or all three of the stimuli employed. This study therefore provides a possible neural correlate of the psychophysical findings that humans can lateralize continuous, complex, high‐frequency stimuli on the basis of interaural time. The data also imply that lateralization of transients may be performed by high‐frequency neurons. [Supported by NIH.]

关键词： 神经生理学