Prognosis and risk factors for cardiac valve calcification in Chinese end-stage kidney disease patients on combination therapy with hemodialysis and hemodiafiltration

作者全名："Xiong, Jian-qiong; Chen, Xue-mei; Liang, Chun-ting; Guo, Wen; Wu, Bai-li; Du, Xiao-gang"

作者地址："[Xiong, Jian-qiong; Liang, Chun-ting; Du, Xiao-gang] Chongqing Med Univ, Dept Nephrol, Affiliated Hosp 1, Youyi Rd 1, Chongqing 400042, Peoples R China; [Xiong, Jian-qiong] Chongqing Univ, Chongqing, Peoples R China; [Chen, Xue-mei; Guo, Wen; Wu, Bai-li] Chongqing Med Univ, Emergency Dept, Affiliated Hosp 1, Chongqing, Peoples R China; [Liang, Chun-ting] Longchang Peoples Hosp, Dept Nephrol, Neijiang, Sichuan, Peoples R China"

通信作者："Du, XG (通讯作者)，Chongqing Med Univ, Dept Nephrol, Affiliated Hosp 1, Youyi Rd 1, Chongqing 400042, Peoples R China."

来源：RENAL FAILURE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000755315100001

JCR分区：Q2

影响因子：3

年份：2022

卷号：44

期号：1

开始页：224

结束页：232

文献类型：Article

关键词：End-stage kidney disease; hemodialysis; hemodiafiltration; cardiac valve calcification; vascular calcification

摘要："Background Cardiac valve calcification (CVC) is an important risk factor for cardiovascular complications. However, limited data are available concerning the prevalence, clinical features and risk factors for CVC in end-stage kidney disease (ESKD) patients. In this study, we aimed to assess these parameters in Chinese ESKD patients receiving combination therapy with hemodialysis and hemodiafiltration. Methods We conducted a cross-sectional study on 293 ESKD patients undergoing combination therapy of hemodialysis and hemodiafiltration at the First Affiliated Hospital of Chongqing Medical University from October 2014 to December 2015. CVC was evaluated via echocardiography. Results ESKD patients with CVC had a higher prevalence of diabetes mellitus, aortic and/or coronary artery calcification, arrhythmia, heart failure and coronary heart disease; increased systolic, diastolic and pulse pressure; longer duration of hemodialysis and hypertension; reduced hemoglobin, albumin and high-density lipoprotein cholesterol levels; and increased serum calcium and calcium-phosphorus product levels compared with those without CVC. Logistic regression analysis showed that increased dialysis duration (p = 0.006, OR = 2.25), serum calcium levels (p = 0.046, OR = 2.04) and pulse pressure (p < 0.001, OR = 3.22), the presence of diabetes (p = 0.037, OR = 1.81) and decreased serum albumin levels (p = 0.047, OR = 0.54) were risk factors for CVC. The correlation analysis indicated a significantly increased CVCs prevalence with an increase prevalence of heart failure, aortic and coronary artery calcification. Conclusions CVC represents a common complication and a danger signal for cardiovascular events in ESKD patients undergoing combination therapy of hemodialysis and hemodiafiltration. The presence of diabetes, increased pulse pressure, long dialysis duration, hypoalbuminemia and high serum calcium levels were independent risk factors for CVC."

基金机构：Department of Nephrology and Emergency Department of the First Affiliated Hospital of Chongqing Medical University

基金资助正文："The authors are very grateful to the team from the Department of Nephrology and Emergency Department of the First Affiliated Hospital of Chongqing Medical University, and all those who have provided support and help for this study."