Alteration of Glycerophospholipid Metabolism in Hippocampus of Post-stroke Depression Rats

作者全名："Jiang, Wenxia; Chen, Jianjun; Gong, Lei; Liu, Fang; Zhao, Huan; Mu, Jun"

作者地址："[Jiang, Wenxia; Gong, Lei; Liu, Fang; Zhao, Huan; Mu, Jun] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, 1 Yixueyuan Rd, Chongqing, Peoples R China; [Chen, Jianjun] Chongqing Med Univ, Inst Life Sci, 1 Yixueyuan Rd, Chongqing, Peoples R China"

通信作者："Mu, J (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, 1 Yixueyuan Rd, Chongqing, Peoples R China."

来源：NEUROCHEMICAL RESEARCH

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000787167500001

JCR分区：Q2

影响因子：4.4

年份：2022

卷号：47

期号：7

开始页：2052

结束页：2063

文献类型：Article

关键词：Post-stroke depression; Hippocampus; Glycerophospholipid; Metabolomics

摘要："Post-stroke depression (PSD) is the most common mental disorder in stroke survivors. However, its specific pathophysiology remains largely unknown. Previous studies suggested a role of hippocampus in PSD. Therefore, we conducted this study to investigate the lipid metabolic signatures in hippocampus of PSD rats. Here, the liquid chromatography mass spectrometry was used to identify the lipid metabolic signatures in the hippocampus of PSD, control and stroke rats. Then, correlations between behavior indices and differential lipid metabolites in PSD rats were explored. Pathway and enrichment analysis were further conducted to uncover the crucial metabolic pathways related to PSD. Finally, we found that the lipid metabolic phenotype in hippocampus of PSD rats was substantially different from that in control and stroke rats, and identified 50 key lipid metabolites that were significantly decreased in PSD rats. These differential metabolites were mainly involved in glycerophospholipid metabolism. Meanwhile, the sucrose preference and immobility time were found to be significantly positively and negatively, respectively, correlated with glycerophospholipid metabolites. The pathway and enrichment analysis showed that the glycerophospholipid metabolism, especially cardiolipin metabolism, was significantly disturbed in PSD rats. These results suggested that the down-regulated glycerophospholipids in hippocampus, especially cardiolipin, might participate in the pathophysiology of PSD. Our findings would be helpful for future exploring the pathophysiology of PSD."

基金机构："National Natural Science Foundation of China [81371310]; Science and Technology Committee of Chongqing [cstc2018jcyjAX0130]; Chongqing Health Commission [2020MSXM038, Z20210305]"

基金资助正文："This article was funded by National Natural Science Foundation of China (Grant No. 81371310), Science and Technology Committee of Chongqing (Grant No. cstc2018jcyjAX0130), Chongqing Health Commission (Grant No. 2020MSXM038), and Special support project for clinical research of young and middle-aged doctors in south of the Five Ridges neurology (Grant No. Z20210305)."