Reduced sleep duration increases the risk of lower urinary tract symptoms suggestive of benign prostatic hyperplasia in middle-aged and elderly males: a national cross-sectional study

作者全名："Xiong, Yang; Zhang, Yangchang; Zhang, Fuxun; Wu, Changjing; Qin, Feng; Yuan, Jiuhong"

作者地址："[Xiong, Yang; Zhang, Fuxun; Wu, Changjing; Qin, Feng; Yuan, Jiuhong] Sichuan Univ, West China Hosp, Androl Lab, Chengdu, Peoples R China; [Xiong, Yang; Zhang, Fuxun; Yuan, Jiuhong] Sichuan Univ, West China Hosp, Dept Urol, Chengdu, Peoples R China; [Zhang, Yangchang] Chongqing Med Univ, Sch Publ Hlth & Management, Dept Epidemiol & Hlth Stat, Chongqing, Peoples R China"

通信作者："Yuan, JH (通讯作者)，Sichuan Univ, West China Hosp, Androl Lab, Chengdu, Peoples R China."

来源：AGING MALE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000802177300001

JCR分区：Q3

影响因子：2.6

年份：2022

卷号：25

期号：1

开始页：159

结束页：166

文献类型：Article

关键词：Benign prostatic hyperplasia; lower urinary tract symptoms; middle-aged and elderly; males; reduced sleep duration

摘要："Background The prevalence of lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH) remains high in men. However, whether reduced sleep duration enhances the risk of LUTS/BPH remains unknown. Materials and methods The 2015 China Health and Retirement Longitudinal Study was used in this study. Binary logistic regression was adopted to test the relationship between sleep duration and LUTS/BPH. Restricted cubic spline (RCS) regression was used to examine the non-linear association. In sensitivity analyses, propensity scores matching was performed to verify the robustness of the results. Results In this study, 8,920 males aged 40 years above were enrolled. In the fully adjusted logistic model, across the quartiles of sleep duration, the odds ratios of LUTS/BPH were 1.00 (reference), 0.94 (95% CI 0.77-1.15), 0.74 (95% CI 0.58-0.94), 0.54 (0.37-0.75), respectively. The results of RCS indicated a non-linear inverted U-shaped association between sleep duration and LUTS/BPH (p for non-linearity <0.05). In the subgroup analyses, no significant effects of settlements, alcohol and cigarette consumption, depression, and hypertension on the association between sleep duration and prevalent LUTS/BPH were observed (p for interaction >0.05). Conclusion Reduced sleep duration is significantly associated with the increases of the LUTS/BPH risk in Chinese middle-aged and elderly males."

基金机构："Natural Science Foundation of China [81871147, 82071639]; Chengdu Science and Technology Program [2019-YFYF-00087-SN]"

基金资助正文："This work was supported by the Natural Science Foundation of China [81871147 & 82071639], and Chengdu Science and Technology Program [2019-YFYF-00087-SN]."