Endovascular treatment for wake-up stroke and daytime unwitnessed stroke: A meta-analysis

作者全名："Qin, Bin; Gao, Wen; Qin, Huixun; Zhao, Libo; Yang, Mingxiu"

作者地址："[Qin, Bin; Gao, Wen; Qin, Huixun; Yang, Mingxiu] Guangxi Med Univ, Liuzhou Peoples Hosp Affiliated, Dept Neurol, Liuzhou, Guangxi, Peoples R China; [Zhao, Libo] Chongqing Med Univ, Yongchuan Hosp, Chongqing, Peoples R China; [Gao, Wen] Guangxi Med Univ, Affiliated Hosp 1, Dept Neurol, Nanning, Guangxi, Peoples R China; [Yang, Mingxiu] Guangxi Med Univ, Liuzhou Peoples Hosp Affiliated, Dept Neurol, Liuzhou 545000, Guangxi, Peoples R China"

通信作者："Yang, MX (通讯作者)，Guangxi Med Univ, Liuzhou Peoples Hosp Affiliated, Dept Neurol, Liuzhou 545000, Guangxi, Peoples R China."

来源：JOURNAL OF CLINICAL NEUROSCIENCE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000809974300003

JCR分区：Q4

影响因子：2

年份：2022

卷号：101

期号：　

开始页：252

结束页：258

文献类型：Article

关键词：Endovascular treatment; Wake-up stroke; Daytime unwitnessed stroke; Meta-analysis

摘要："Background: Evidence from sources outside the typical clinical research setting, such as a real-world setting, may complement evidence from randomised controlled trials (RCTs). The aim of the present study was to carry out a meta-analysis of available real-world evidence that focused on the efficacy and safety of endovascular treatment in patients with wake-up stroke (WUS) or daytime unwitnessed stroke (DUS) compared to that in patients treated <= 6 h after the onset of an ischemic stroke. Methods: Data mining was conducted on 1 May 2021 from PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials Cochrane Library. The study reviewed all published that assessed the effect of endovascular treatment in WUS and DUS compared to that received by patients with ischemic stroke. Relevant data were extracted and the narrative was reviewed and analysed. The results were expressed as odds ratios (ORs) with 95% confidence intervals (CIs). Findings: The meta-analysis showed no significant differences between the two groups in the rates of functional independence (OR, 0.81; 95% CI, 0.65-1.02; P = 0.07), symptomatic intracerebral haemorrhage (OR, 0.86; 95% CI, 0.57-1.30; P = 0.470), and all-cause mortality (OR, 0.92; 95% CI, 0.73-1.16; P = 0.50). There was also no heterogeneity between the trials. Conclusion: The pooled analysis provided evidence to support the use of endovascular treatment in WUS and DUS with favourable perfusion imaging. The meta-analysis confirmed the main findings of RCTs of endovascular treatment in WUS and DUS in a real-world setting and therefore strengthens the validity of this treatment strategy."

基金机构：Liuzhou science and tech-nology project [2018AF10502]

基金资助正文：Funding This work was financially supported by Liuzhou science and tech-nology project (2018AF10502) .