Differential Gut Microbiota Compositions Related With the Severity of Major Depressive Disorder

作者全名："Zhong, Qi; Chen, Jian-jun; Wang, Ying; Shao, Wei-hua; Zhou, Chan-juan; Xie, Peng"

作者地址："[Zhong, Qi; Chen, Jian-jun] Chongqing Med Univ, Inst Life Sci, Chongqing, Peoples R China; [Wang, Ying] Chongqing Med Univ, Dept Rehabil, Affiliated Hosp 2, Chongqing, Peoples R China; [Shao, Wei-hua] Chongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Chongqing, Peoples R China; [Zhou, Chan-juan] Chongqing Med Univ, Cent Lab, Yongchuan Hosp, Chongqing, Peoples R China; [Xie, Peng] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China; [Xie, Peng] Chongqing Med Univ, NHC Key Lab Diag & Treatment Brain Funct Dis, Affiliated Hosp 1, Chongqing, Peoples R China"

通信作者："Xie, P (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China.; Xie, P (通讯作者)，Chongqing Med Univ, NHC Key Lab Diag & Treatment Brain Funct Dis, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:000831162400001

JCR分区：Q1

影响因子：5.7

年份：2022

卷号：12

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：major depressive disorder; gut microbiota; Firmicutes; Actinobacteriota; Bacteroidota

摘要："ObjectiveIncreasing evidence shows a close relationship between gut microbiota and major depressive disorder (MDD), but the specific mechanisms remain unknown. This study was conducted to explore differential gut microbiota compositions related to the severity of MDD. MethodsHealthy controls (HC) (n = 131) and MDD patients (n = 130) were included. MDD patients with Hamilton Depression Rating Scale (HDRS) score <25 and >= 25 were assigned into moderate (n = 72) and severe (n = 58) MDD groups, respectively. Univariate and multivariate analyses were used to analyze the gut microbiota compositions at the genus level. ResultsThirty-six and 27 differential genera were identified in moderate and severe MDD patients, respectively. The differential genera in moderate and severe MDD patients mainly belonged to three (Firmicutes, Actinobacteriota, and Bacteroidota) and two phyla (Firmicutes and Bacteroidota), respectively. One specific covarying network from phylum Actinobacteriota was identified in moderate MDD patients. In addition, five genera (Collinsella, Eggerthella, Alistipes, Faecalibacterium, and Flavonifractor) from the shared differential genera by two MDD groups had a fair efficacy in diagnosing MDD from HC (AUC = 0.786). ConclusionsOur results were helpful for further exploring the role of gut microbiota in the pathogenesis of depression and developing objective diagnostic methods for MDD."

基金机构："National Key Research and Development Program of China [2017YFA0505700]; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2019PT320002]; Natural Science Foundation Project of China [81820108015, 81701360]; Natural Science Foundation of Chongqing [cstc2021jcyj-msxmX0084]; Science and Technology Research Program of Chongqing Municipal Education Commission [KJQN202100420]; Chongqing Yuzhong District Science & Technology Commission [20190115]"

基金资助正文："This work was supported by the National Key Research and Development Program of China (2017YFA0505700), the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2019PT320002), the Natural Science Foundation Project of China (81820108015, 81701360), the Natural Science Foundation of Chongqing (cstc2021jcyj-msxmX0084), the Science and Technology Research Program of Chongqing Municipal Education Commission (Grant No. KJQN202100420), and the Chongqing Yuzhong District Science & Technology Commission (20190115)."