Tailored Target Ablation Index Guided Pulmonary Vein Isolation in Treating Paroxysmal Atrial Fibrillation: A Single Center Randomized Study in Asian Population (AI-Asian-I)

作者全名："Xiong, Qingsong; Liao, Jia; Chen, Weijie; Xiao, Peilin; Du, Huaan; He, Qushuai; Yin, Yuehui; Ling, Zhiyu; Chen, Shaojie"

作者地址："[Xiong, Qingsong; Liao, Jia; Chen, Weijie; Xiao, Peilin; Du, Huaan; He, Qushuai; Yin, Yuehui; Ling, Zhiyu; Chen, Shaojie] Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 2, Chongqing, Peoples R China; [Chen, Shaojie] Cardioangiol Centrum Bethanien CCB, Frankfurt, Germany"

通信作者："Ling, ZY; Chen, SJ (通讯作者)，Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 2, Chongqing, Peoples R China."

来源：FRONTIERS IN CARDIOVASCULAR MEDICINE

ESI学科分类：　

WOS号：WOS:000831728500001

JCR分区：Q2

影响因子：3.6

年份：2022

卷号：9

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：atrial fibrillation; ablation index; pulmonary vein isolation; randomized; recurrence

摘要："Objective: To evaluate the efficacy and safety of lower ablation indexes (AI) guided pulmonary vein isolation (PVI) in treating paroxysmal atrial fibrillation (AF). Methods: Ninety patients with paroxysmal AF scheduled for radiofrequency ablation were randomly divided into three groups. The AI targets for PVI were as follows: In group A/B/C, 550/500/450 for roof and anterior wall, and 400/350/300 for posterior/inferior wall. The first-pass PVI rate, ablation time, complications and recurrence of atrial tachyarrhythmia (ATa) were compared. Results: The mean age was 62.5 years (male: 63.0%), mean body mass index (BMI): 24.35 & PLUSMN; 3.66 kg/m(2). The baseline characteristics were comparable. There was no significant difference in the first-pass PVI rate among the three groups (left-sided-PV: 66.7% vs. 80% vs. 73.3%, P = 0.51; right-sided-PV: 70% vs. 83.3% vs. 73.3%, P = 0.64), also with similar gap rate during the procedural waiting time. At 1-year follow-up there was no significant difference in the recurrence rate of ATa among the three groups (10% vs. 13.3% vs. 13.3%, P = 1.00). The ablation time in the Group C was significantly less than that in the other two groups (47.8 min. vs. 47.0 min. vs. 36.6 min, P < 0.001). Higher AI seemed to link a non-significant trend toward higher rate of pericardial effusion (group A + B vs. group C:6.7% vs. 0%, P = 0.30), although the rate of overall complications was not different among the three groups. Conclusion: This randomized study shows that, a relatively lower target AI guided ablation may be similarly effective to achieve PVI with significantly reduced ablation time and obtain similar clinical outcome in treating paroxysmal AF in Asian population."

基金机构："Joint Medical Research Project of Chongqing Municipal Health Commission; Chongqing Science and Technology Bureau [2018ZDXM015]; Future Young Medical innovation Team of Chongqing Medical University [W0078]; Kuanren Talents Program of Second Affiliated Hospital of Chongqing Medical University, Chongqing, China [(2020)7]"

基金资助正文："This study was partly supported by Joint Medical Research Project of Chongqing Municipal Health Commission and Chongqing Science and Technology Bureau (Grant No. 2018ZDXM015) (ZL), Future Young Medical innovation Team of Chongqing Medical University (Grant No. W0078) (ZL), and Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China [Grant No. (2020)7] (ZL)."