"Associations between short-term exposure of ambient particulate matter and hemodialysis patients death: A nationwide, longitudinal case-control study in China"

作者全名："Lou, Xiaowei; Zhang, Ping; Shi, Nan; Ding, Zhe; Xu, Zhonggao; Liu, Bicheng; Hu, Wenbo; Yan, Tiekun; Wang, Jinwen; Liu, Ling; Zha, Yan; Wang, Jianqin; Chen, Wei; Xu, Chenyun; Xu, Jinsheng; Jiang, Hongli; Ma, Huichao; Yuan, Weijie; Wang, Caili; Liao, Yunhua; Wang, Deguang; Yao, Li; Chen, Menghua; Li, Guisen; Li, Yun; Wang, Pei; Li, Xuemei; Lu, Chen; Tang, Wenzhuang; Wan, Jianxin; Li, Rongshan; Xiao, Xiangcheng; Zhang, Chun; Jiao, Jundong; Zhang, Wei; Yuan, Jing; Lan, Lan; Li, Jingsong; Zhang, Peng; Zheng, Weijun; Chen, Jianghua"

作者地址："[Lou, Xiaowei; Zhang, Ping; Shi, Nan; Li, Guisen; Zheng, Weijun; Chen, Jianghua] Zhejiang Univ, Af fi liated Hosp 1, Coll Med, Kidney Dis Ctr, Hangzhou, Peoples R China; [Lou, Xiaowei; Zhang, Ping; Shi, Nan; Li, Guisen] Natl Key Clin Dept Kidney Dis, Hangzhou, Peoples R China; [Lou, Xiaowei; Zhang, Ping; Shi, Nan; Li, Guisen] Zhejiang Univ, Inst Nephropathy, Hangzhou, Peoples R China; [Lou, Xiaowei; Ding, Zhe] Zhejiang Univ, Coll Med, Hangzhou, Peoples R China; [Zhang, Ping] Zhejiang Dialysis Qual Control Ctr, Hangzhou, Peoples R China; [Shi, Nan] Zhejiang Chinese Med Univ, Sch Publ Hlth, Hangzhou, Peoples R China; [Xu, Zhonggao] Zhejiang Univ, Sch Math Sci, Hangzhou, Peoples R China; [Xu, Zhonggao] First Hosp Jilin Univ, Jilin, Peoples R China; [Liu, Bicheng] Affiliated Zhongda Hosp Southeast Univ, Hangzhou, Peoples R China; [Hu, Wenbo] Qinghai Prov Peoples Hosp, Hangzhou, Peoples R China; [Yan, Tiekun] Tianjin Med Univ Gen Hosp, Tianjin, Peoples R China; [Wang, Jinwen] Yanan Hosp Kunming Med Univ, Kunming, Peoples R China; [Liu, Ling] Second Af fi liated Hosp Chongqing Med Univ, Chongqing, Peoples R China; [Zha, Yan] Guizhou Prov Peoples Hosp, Guizhou, Peoples R China; [Wang, Jianqin] Second Af fi liated Hosp Lanzhou Univ, Lanzhou, Peoples R China; [Chen, Wei] Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou, Peoples R China; [Xu, Chenyun] Second Affiliated Hosp Nanchang Univ, Nanchang, Peoples R China; [Xu, Jinsheng] Fourth Hosp Hebei Med Univ, Hebei, Peoples R China; [Jiang, Hongli] First Af fi liated Hosp Xian Jiaotong Univ, Xian, Peoples R China; [Ma, Huichao] Second Hosp Tibet Autonomous Reg, Hangzhou, Peoples R China; [Yuan, Weijie] Shanghai First Peoples Hosp, Shanghai, Peoples R China; [Wang, Caili] First Affiliated Hosp Baotou Med Coll, Baotou, Peoples R China; [Liao, Yunhua] First Af fi liated Hosp Guangxi Med Univ, Guangxi, Peoples R China; [Wang, Deguang] Second Affiliated Hosp Anhui Med Univ, Hefei, Peoples R China; [Yao, Li] First Af fi liated Hosp China Med Univ, Hangzhou, Peoples R China; [Li, Yun; Wang, Pei; Li, Xuemei; Lu, Chen; Tang, Wenzhuang; Li, Rongshan; Xiao, Xiangcheng; Zhang, Chun; Jiao, Jundong; Zhang, Wei; Yuan, Jing; Lan, Lan; Li, Jingsong; Zhang, Peng; Zheng, Weijun; Chen, Jianghua] Gen Hosp Ningxia Med Univ, Ningxia, Peoples R China; [Li, Yun; Wang, Pei; Li, Xuemei; Lu, Chen; Tang, Wenzhuang; Li, Rongshan; Xiao, Xiangcheng; Zhang, Chun; Jiao, Jundong; Zhang, Wei; Yuan, Jing; Lan, Lan; Li, Jingsong; Zhang, Peng; Zheng, Weijun; Chen, Jianghua] Sichuan Prov Peoples Hosp, Chengdu, Peoples R China; [Li, Yun; Wang, Pei; Li, Xuemei; Lu, Chen; Tang, Wenzhuang; Li, Rongshan; Xiao, Xiangcheng; Zhang, Chun; Jiao, Jundong; Zhang, Wei; Yuan, Jing; Lan, Lan; Li, Jingsong; Zhang, Peng; Zheng, Weijun; Chen, Jianghua] Jiangxi Prov Peoples Hosp, Jiangxi, Peoples R China; [Li, Yun; Wang, Pei; Li, Xuemei; Lu, Chen; Tang, Wenzhuang; Li, Rongshan; Xiao, Xiangcheng; Zhang, Chun; Jiao, Jundong; Zhang, Wei; Yuan, Jing; Lan, Lan; Li, Jingsong; Zhang, Peng; Zheng, Weijun; Chen, Jianghua] First Af fi liated Hosp Zhengzhou Univ, Zhengzhou, Peoples R China; [Li, Yun; Wang, Pei; Li, Xuemei; Lu, Chen; Tang, Wenzhuang; Li, Rongshan; Xiao, Xiangcheng; Zhang, Chun; Jiao, Jundong; Zhang, Wei; Yuan, Jing; Lan, Lan; Li, Jingsong; Zhang, Peng; Zheng, Weijun; Chen, Jianghua] Peking Union Med Coll Hosp, Shanghai, Peoples R China; [Li, Yun; Wang, Pei; Li, Xuemei; Lu, Chen; Tang, Wenzhuang; Li, Rongshan; Xiao, Xiangcheng; Zhang, Chun; Jiao, Jundong; Zhang, Wei; Yuan, Jing; Lan, Lan; Li, Jingsong; Zhang, Peng; Zheng, Weijun; Chen, Jianghua] Peoples Hosp Xinjiang Uygur Autonomous Reg, Xinjiang, Peoples R China; [Li, Yun; Wang, Pei; Li, Xuemei; Lu, Chen; Tang, Wenzhuang; Li, Rongshan; Xiao, Xiangcheng; Zhang, Chun; Jiao, Jundong; Zhang, Wei; Yuan, Jing; Lan, Lan; Li, Jingsong; Zhang, Peng; Zheng, Weijun; Chen, Jianghua] Af fi liated Hosp Hainan Med Coll, Hainan, Peoples R China; [Li, Yun; Wang, Pei; Li, Xuemei; Lu, Chen; Tang, Wenzhuang; Li, Rongshan; Xiao, Xiangcheng; Zhang, Chun; Jiao, Jundong; Zhang, Wei; Yuan, Jing; Lan, Lan; Li, Jingsong; Zhang, Peng; Zheng, Weijun; Chen, Jianghua] First Af fi liated Hosp Fujian Med Univ, Fujjian, Peoples R China; [Li, Yun; Wang, Pei; Li, Xuemei; Lu, Chen; Tang, Wenzhuang; Li, Rongshan; Xiao, Xiangcheng; Zhang, Chun; Jiao, Jundong; Zhang, Wei; Yuan, Jing; Lan, Lan; Li, Jingsong; Zhang, Peng; Zheng, Weijun; Chen, Jianghua] Shanxi Prov Peoples Hosp, Shanxi, Peoples R China; [Li, Yun; Wang, Pei; Li, Xuemei; Lu, Chen; Tang, Wenzhuang; Li, Rongshan; Xiao, Xiangcheng; Zhang, Chun; Jiao, Jundong; Zhang, Wei; Yuan, Jing; Lan, Lan; Li, Jingsong; Zhang, Peng; Zheng, Weijun; Chen, Jianghua] Xiangya Hosp Cent South Univ, Xiangya, PR, Brazil; [Zhang, Chun] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Hangzhou, Peoples R China; [Jiao, Jundong] Second Af fi liated Hosp Harbin Med Univ, Harbin, Peoples R China; [Li, Jingsong] Res Ctr Healthcare Data Sci, Zhejiang Lab, Zhejiang, Peoples R China; [Zhang, Peng] Zhejiang Univ, Sch Math Sci, Ouyangchunmei Sci Bldg, 38 Zheda Rd,Yuquan Campus, Hangzhou, Peoples R China"

通信作者："Zheng, WJ; Chen, JH (通讯作者)，Zhejiang Univ, Af fi liated Hosp 1, Coll Med, Kidney Dis Ctr, Hangzhou, Peoples R China.; Zhang, P; Zheng, WJ; Chen, JH (通讯作者)，Gen Hosp Ningxia Med Univ, Ningxia, Peoples R China.; Zhang, P; Zheng, WJ; Chen, JH (通讯作者)，Sichuan Prov Peoples Hosp, Chengdu, Peoples R China.; Zhang, P; Zheng, WJ; Chen, JH (通讯作者)，Jiangxi Prov Peoples Hosp, Jiangxi, Peoples R China.; Zhang, P; Zheng, WJ; Chen, JH (通讯作者)，First Af fi liated Hosp Zhengzhou Univ, Zhengzhou, Peoples R China.; Zhang, P; Zheng, WJ; Chen, JH (通讯作者)，Peking Union Med Coll Hosp, Shanghai, Peoples R China.; Zhang, P; Zheng, WJ; Chen, JH (通讯作者)，Peoples Hosp Xinjiang Uygur Autonomous Reg, Xinjiang, Peoples R China.; Zhang, P; Zheng, WJ; Chen, JH (通讯作者)，Af fi liated Hosp Hainan Med Coll, Hainan, Peoples R China.; Zhang, P; Zheng, WJ; Chen, JH (通讯作者)，First Af fi liated Hosp Fujian Med Univ, Fujjian, Peoples R China.; Zhang, P; Zheng, WJ; Chen, JH (通讯作者)，Shanxi Prov Peoples Hosp, Shanxi, Peoples R China.; Zhang, P; Zheng, WJ; Chen, JH (通讯作者)，Xiangya Hosp Cent South Univ, Xiangya, PR, Brazil.; Zhang, P (通讯作者)，Zhejiang Univ, Sch Math Sci, Ouyangchunmei Sci Bldg, 38 Zheda Rd,Yuquan Campus, Hangzhou, Peoples R China."

来源：SCIENCE OF THE TOTAL ENVIRONMENT

ESI学科分类：ENVIRONMENT/ECOLOGY

WOS号：WOS:000859186900007

JCR分区：Q1

影响因子：9.8

年份：2022

卷号：852

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Hemodialysis; Mortality; Short-term exposure; Ambient PM2.5

摘要："Background: Long-term exposure to particulate air pollutants can lead to an increase in mortality of hemodialysis patients, but evidence of mortality risk with short-term exposure to ambient particulate matter is lacking. This study aimed to estimate the association of short-term exposure to ambient particulate matter across a wide range of concentrations with hemodialysis patients mortality. Methods: We performed a time-stratified case-crossover study to estimate the association between short-term exposures to PM2.5 and PM10 and mortality of hemodialysis patients. The study included 18,114 hemodialysis death case from 279 hospitals in 41 cities since 2013. Daily particulate matter exposures were calculated by the inverse distance-weighted model based on each case's dialysis center address. Conditional logistic regression were implemented to quantify exposure-response associations. The sensitivity analysis mainly explored the lag effect of particulate matter. Results: During the study period, there were 18,114 case days and 61,726 control days. Of all case and control days, average PM2.5 and PM10 levels were 43.98 mu g/m(3) and 70.86 mu g/m(3), respectively. Each short-term increase of 10 mu g/m(3) in PM2.5 and PM10 were statistically significantly associated with a relative increase of 1.07 % (95 % confidence interval [CI]: 0.99 % - 1.15 %) and 0.89 % (95 % CI: 0.84 % - 0.94 %) in daily mortality rate of hemodialysis patients, respectively. There was no evidence of a threshold in the exposure-response relationship. The mean of daily exposure on the same day of death and one-day prior (Lag 01 Day) was the most plausible exposure time window. Conclusions: This study confirms that short-term exposure to particulate matter leads to increased mortality in hemodialysis patients. Policy makers and public health practices have a clear and urgent opportunity to pass air quality control policies that care for hemodialysis populations and incorporate air quality into the daily medical management of hemodialysis patients."

基金机构：Provincial Ministry of Health and Planning Commission of Zhejiang Province; Major Scientific Project of Zhejiang Lab [2016153789]; Medicine and Health Science and Technology Project of Zhejiang Province [2020ND8AD01]; [2022PY010]

基金资助正文：This work was supported by Provincial Ministry of Health and Planning Commission of Zhejiang Province (No. 2016153789); Major Scientific Project of Zhejiang Lab (No. 2020ND8AD01); Medicine and Health Science and Technology Project of Zhejiang Province (No. 2022PY010). No financial relationships with any organisations that might have an interest in the submitted work in the previous three years; no other relationships or activities that could appear to have influenced the submitted work