Toward a Deeper Understanding of Gut Microbiome in Depression: The Promise of Clinical Applicability

作者全名："Liu, Lanxiang; Wang, Haiyang; Zhang, Hanping; Chen, Xueyi; Zhang, Yangdong; Wu, Ji; Zhao, Libo; Wang, Dongfang; Pu, Juncai; Ji, Ping; Xie, Peng"

作者地址："[Liu, Lanxiang; Zhao, Libo; Xie, Peng] Chongqing Med Univ, Dept Neurol, Yongchuan Hosp, Chongqing 402160, Peoples R China; [Liu, Lanxiang; Wang, Haiyang; Zhang, Hanping; Chen, Xueyi; Zhang, Yangdong; Wu, Ji; Wang, Dongfang; Pu, Juncai; Xie, Peng] Chongqing Med Univ, NHC Key Lab Diag & Treatment Brain Funct Dis, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Liu, Lanxiang; Zhang, Hanping; Zhang, Yangdong; Wu, Ji; Pu, Juncai; Xie, Peng] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Wang, Haiyang; Ji, Ping; Xie, Peng] Chongqing Med Univ, Coll Stomatol, Chongqing 401147, Peoples R China; [Wang, Haiyang; Ji, Ping; Xie, Peng] Chongqing Med Univ, Affiliated Stomatol Hosp, Chongqing 401147, Peoples R China"

通信作者："Xie, P (通讯作者)，Chongqing Med Univ, Dept Neurol, Yongchuan Hosp, Chongqing 402160, Peoples R China.; Xie, P (通讯作者)，Chongqing Med Univ, NHC Key Lab Diag & Treatment Brain Funct Dis, Affiliated Hosp 1, Chongqing 400016, Peoples R China.; Xie, P (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing 400016, Peoples R China.; Xie, P (通讯作者)，Chongqing Med Univ, Coll Stomatol, Chongqing 401147, Peoples R China.; Xie, P (通讯作者)，Chongqing Med Univ, Affiliated Stomatol Hosp, Chongqing 401147, Peoples R China."

来源：ADVANCED SCIENCE

ESI学科分类：PHYSICS

WOS号：WOS:000871902500001

JCR分区：Q1

影响因子：15.1

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：depression; gut microbiome; microbial biomarkers; microbiota-based therapeutics; precision medicine

摘要："The emergence of the coronavirus disease 2019 pandemic has dramatically increased the global prevalence of depression. Unfortunately, antidepressant drugs benefit only a small minority of patients. Thus, there is an urgent need to develop new interventions. Accumulating evidence supports a causal relationship between gut microbiota dysbiosis and depression. To advance microbiota-based diagnostics and therapeutics of depression, a comprehensive overview of microbial alterations in depression is presented to identify effector microbial biomarkers. This procedure generated 215 bacterial taxa from humans and 312 from animal models. Compared to controls, depression shows significant differences in beta-diversity, but no changes in microbial richness and diversity. Additionally, species-specific microbial changes are identified like increased Eggerthella in humans and decreased Acetatifactor in rodent models. Moreover, a disrupted microbiome balance and functional changes, characterized by an enrichment of pro-inflammatory bacteria (e.g., Desulfovibrio and Escherichia/Shigella) and depletion of anti-inflammatory butyrate-producing bacteria (e.g., Bifidobacterium and Faecalibacterium) are consistently shared across species. Confounding effects of geographical region, depression type, and intestinal segments are also investigated. Ultimately, a total of 178 species and subspecies probiotics are identified to alleviate the depressive phenotypes. Current findings provide a foundation for developing microbiota-based diagnostics and therapeutics and advancing microbiota-oriented precision medicine for depression."

基金机构："Natural Science Foundation Project of China [81820108015, 82201683]; China Postdoctoral Science Foundation [2020TQ0393, 2020M683634XB, 2021M693926]; Chongqing Science & Technology Commission [cstc2021jcyj-bshX0201, cstc2021jcyj-bshX0150]"

基金资助正文："This work was supported by a grant from the Natural Science Foundation Project of China (No. 81820108015 and No. 82201683), the China Postdoctoral Science Foundation (No. 2020TQ0393, No. 2020M683634XB, and No. 2021M693926), and the Chongqing Science & Technology Commission (No. cstc2021jcyj-bshX0201 andNo. cstc2021jcyj-bshX0150). The authors thank K. Hashimoto for providing raw data. Some vectormaterials are drawn by Figdraw (www.figdraw.com)."