Clinical and Computed Tomography Characteristics of Solitary Pulmonary Nodules Caused by Fungi: A Comparative Study

作者全名："Jiang, Jin; Lv, Zhuo-ma; Lv, Fa-jin; Fu, Bin-jie; Liang, Zhang-rui; Chu, Zhi-gang"

作者地址："[Jiang, Jin; Lv, Zhuo-ma; Lv, Fa-jin; Fu, Bin-jie; Liang, Zhang-rui; Chu, Zhi-gang] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China; [Lv, Zhuo-ma] Second Peoples Hosp, Dept Radiol, Chongqing, Peoples R China; [Chu, Zhi-gang] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Yuanjiagang, Peoples R China"

通信作者："Chu, ZG (通讯作者)，Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Yuanjiagang, Peoples R China."

来源：INFECTION AND DRUG RESISTANCE

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000875641600001

JCR分区：Q2

影响因子：3.9

年份：2022

卷号：15

期号：　

开始页：6019

结束页：6028

文献类型：Article

关键词：tomography; X-ray computed; pulmonary nodules; fungal infection

摘要："Purpose: To clarify the clinical and computed tomography (CT) indicators in distinguishing pulmonary nodules caused by fungal infection from lung cancers.Methods: From January 2013 to April 2022, 68 patients with solitary fungal nodules (64 were solid and 4 were mixed ground-glass nodules) and 140 cases with solid cancerous nodules with similar size were enrolled. Their clinical characteristics and CT manifesta-tions of the solid nodules were summarized and compared, respectively.Results: Compared with patients with lung cancers, cases were younger (51.2 +/- 11.5 vs 61.3 +/- 10.2 years) and non-smokers (72.1% vs 57.9%) and immunocompromised (44.1% vs 17.9%) individuals were more common in patients with fungal nodules (each P < 0.05). The air crescent sign (ACS) (34.4% vs 0%), halo sign (HS) (23.4% vs 4.3%), and satellite lesions (45.3% vs 2.9%) were more frequently detected in fungal nodules than in cancerous ones (each P < 0.05). Air bronchogram similarly occurred in fungal and cancerous nodules, whereas the natural ones were more common in the former (100% vs 16.7%, P = 0.000). However, the fungal nodules had a lower enhancement degree (29.0 +/- 19.2 HU vs 40.3 +/- 28.3 HU, P = 0.038) and frequency of hilar and/or mediastinal lymph node enlargement (2.9% vs 14.3%, P = 0.013) compared with the cancerous nodules. Conclusion: In the younger, non-smoking and immunocompromised patients, a solitary pulmonary solid nodule with ACS, HS, satellite lesions and/or natural air bronchogram but without significant enhancement, fungal infection is a probable diagnosis."

基金机构：Joint Project of Chongqing Science and Technology Commission; Chongqing Public Health Commission [2022MSXM050]; Senior Medical Talents Program of Chongqing for Young and Middle-aged from Chongqing Health Commission

基金资助正文：This work was supported by the Joint Project of Chongqing Science and Technology Commission and Chongqing Public Health Commission (2022MSXM050) and the Senior Medical Talents Program of Chongqing for Young and Middle-aged from Chongqing Health Commission (Receptor: Zhi-gang Chu).