Orientation dependence of R-2 relaxation in the newborn brain

作者全名："Bartels, Lara M.; Doucette, Jonathan; Birkl, Christoph; Zhang, Yuting; Weber, Alexander M.; Rauscher, Alexander"

作者地址："[Bartels, Lara M.; Doucette, Jonathan; Rauscher, Alexander] Univ British Columbia, Dept Phys & Astron, Vancouver, BC V6T 1Z1, Canada; [Bartels, Lara M.; Doucette, Jonathan; Birkl, Christoph; Weber, Alexander M.; Rauscher, Alexander] Univ British Columbia, UBC MRI Res Ctr, Vancouver, BC V6T 2B5, Canada; [Bartels, Lara M.; Doucette, Jonathan; Weber, Alexander M.; Rauscher, Alexander] Univ British Columbia, Dept Pediat, Div Neurol, Vancouver, BC V6H 3V4, Canada; [Birkl, Christoph] Med Univ Innsbruck, Dept Neuroradiol, A-6020 Innsbruck, Austria; [Zhang, Yuting] Chongqing Med Univ, Dept Radiol, Childrens Hosp, Chongqing, Peoples R China; [Zhang, Yuting] Chongqing Med Univ, Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China; [Zhang, Yuting] Chongqing Med Univ, Key Lab Pediat, Chongqing, Peoples R China; [Zhang, Yuting] Chongqing Int Sci & Technol Cooperat Ctr Child Dev, Chongqing, Peoples R China; [Rauscher, Alexander] Univ British Columbia, Djavad Mowafaghian Ctr Brain Hlth, Vancouver, BC V6T 1Z3, Canada; [Bartels, Lara M.] Univ British Columbia, Dept Phys & Astron, Vancouver, BC, Canada"

通信作者："Bartels, LM (通讯作者)，Univ British Columbia, Dept Phys & Astron, Vancouver, BC, Canada."

来源：NEUROIMAGE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000880156100001

JCR分区：Q1

影响因子：5.7

年份：2022

卷号：264

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：T-2 anisotropy; Fiber orientation; Neonates; White matter microstructure; Dipole-dipole interaction

摘要："In MRI the transverse relaxation rate, R-2 = 1 /T-2 , shows dependence on the orientation of ordered tissue relative to the main magnetic field. In previous studies, orientation effects of R-2 relaxation in the mature brain's white matter have been found to be described by a susceptibility-based model of diffusion through local magnetic field inhomogeneities created by the diamagnetic myelin sheaths. Orientation effects in human newborn white matter have not yet been investigated. The newborn brain is known to contain very little myelin and is therefore expected to exhibit a decrease in orientation dependence driven by susceptibility-based effects. We measured R-2 orientation dependence in the white matter of human newborns. R-2 data were acquired with a 3D Gradient and Spin Echo (GRASE) sequence and fiber orientation was mapped with diffusion tensor imaging (DTI). We found orientation dependence in newborn white matter that is not consistent with the susceptibility-based model and is best described by a model of residual dipolar coupling. In the near absence of myelin in the newborn brain, these findings suggest the presence of residual dipolar coupling between rotationally restricted water molecules. This has important implications for quantitative imaging methods such as myelin water imaging, and suggests orientation dependence of R-2 as a potential marker in early brain development."

基金机构：Natural Sciences and Engineering Research Council of Canada [2021-04085]; Canada Research Chairs [950-230363]; German National Academic Foundation (Studienstiftung des Deutschen Volkes); NSERC; Izaak Walton Killam Memorial Pre-Doctoral Fellowship

基金资助正文："This work was funded by the Natural Sciences and Engineering Research Council of Canada (grant number 2021-04085) . A.R. is supported by Canada Research Chairs (950-230363) . L.B. holds a scholarship from the German National Academic Foundation (Studienstiftung des Deutschen Volkes) . J.D. is supported by NSERC Doctoral Award and Izaak Walton Killam Memorial Pre-Doctoral Fellowship. UBC Vancouver is located on the traditional, ancestral, and unceded territory of the Musqueam people."