Is Helicobacter pylori infection associated with osteoporosis? a systematic review and meta-analysis

作者全名："Xiong, Chuang; Zhao, Runhan; Xu, Jingtao; Liang, Hao; Zhang, Jun; Huang, Yanran; Luo, Xiaoji"

作者地址："[Xiong, Chuang; Zhao, Runhan; Xu, Jingtao; Liang, Hao; Zhang, Jun; Huang, Yanran; Luo, Xiaoji] Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Luo, Xiaoji] Chongqing Med Univ, Orthoped Lab, Chongqing, Peoples R China"

通信作者："Luo, XJ (通讯作者)，Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China.; Luo, XJ (通讯作者)，Chongqing Med Univ, Orthoped Lab, Chongqing, Peoples R China."

来源：JOURNAL OF BONE AND MINERAL METABOLISM

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000880270400001

JCR分区：Q3

影响因子：3.3

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：Helicobacter pylori; Osteoporosis; CagA-positive Helicobacter pylori; Bone mineral density; Meta-analysis

摘要："Introduction This study used systematic review and meta-analysis to evaluate the association between Helicobacter pylori infection and osteoporosis. Materials and methods PubMed, Ovid and Web of Science were searched to include observational studies published in English comparing bone mineral density changes between Helicobacter pylori-positive and -negative participants. The quality of the included literature was assessed using the Newcastle-Ottawa Quality Assessment Scale (NOS). R software was used for meta-analysis, and odds ratio (OR) and 95% confidence interval (CI) were calculated to evaluate the relationship between Helicobacter pylori infection and osteoporosis. Results Twenty-two studies involving 24,176 participants were included in the study. Our meta-analysis showed that Helicobacter pylori infection was significantly associated with the risk of osteoporosis (OR: 1.12, 95%CI: 1.03, 1.22). Participants infected with the CagA-positive Helicobacter pylori strain were more likely to develop osteoporosis (OR = 1.42, 95%CI: 1.09; 1.85). Conclusion Infection with Helicobacter pylori, particularly the CagA-positive strain, has been associated with an increased risk of osteoporosis. The bone health of Helicobacter pylori-positive patients deserves more attention."

基金机构：National Natural Science Foundation of China [81873998]

基金资助正文：This work was supported by the National Natural Science Foundation of China (81873998).