"Clinical Efficacy of Tandospirone on Functional Dyspepsia Patients with Anxiety: A Randomized, Placebo-Controlled Study"

作者全名："Liu, Lulu; Yang, Wenguang; Lu, Ya; Wang, Jue; Zheng, Yan; Gu, Sai"

作者地址："[Liu, Lulu; Yang, Wenguang; Lu, Ya; Wang, Jue; Zheng, Yan; Gu, Sai] Chongqing Med Univ, Dept Gastroenterol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 40016, Peoples R China"

通信作者："Gu, S (通讯作者)，Chongqing Med Univ, Dept Gastroenterol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 40016, Peoples R China."

来源：DIGESTIVE DISEASES AND SCIENCES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000884632600002

JCR分区：Q3

影响因子：3.1

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Functional dyspepsia; Anxiety; Tandospirone; Brain-derived neurotrophic factor; Inflammatory cytokines

摘要："Background Functional dyspepsia (FD) is characterized with multiple symptoms of indigestion and often accompanied with anxiety. However, there is currently an absence of effective treatment. Tandospirone is commonly used to treat generalized anxiety disorders. Whether tandospirone can improve the clinical symptoms of FD remain unknown. Aims The present study was designed to explore the pharmacological effect of tandospirone on FD patient with anxiety, and the potential mechanisms were also elucidated. Methods FD patients with anxiety were randomly divided into placebo and tandospirone treatment groups. Healthy volunteers were simultaneously recruited as control group. The gastrointestinal symptom score (GIS) and Hamilton anxiety scale (HAM-A) were performed before and after treatments with placebo or tandospirone. The serum levels of brain-derived neurotrophic factor (BDNF) and multiple inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), and interleukin (IL)-6, IL-4, IL-1 beta, and IL-10 were determined. Regression analyses relating BDNF levels and gastrointestinal symptoms were performed. Results Tandospirone significantly alleviated the gastrointestinal and anxiety symptoms of FD patient, as evidenced by reductions of GIS index and HAM-A scores. Compared with the healthy volunteers, FD patients had lower BDNF and IL-10 levels, but higher levels of IL-6 and TNF-alpha. Importantly, tandospirone increased serum BDNF and IL-10 and decreased IL-6 levels in FD patients. Relative analysis revealed that BDNF level was negatively associated with gastrointestinal symptoms in FD patients. Conclusion Tandospirone effectively improved both anxiety and gastrointestinal symptoms of patients with FD, and these therapeutic effects may be associated with the modulation of BDNF and inflammatory cytokines."

基金机构：West China Psychiatric Association [2016-19]; Training Fund of the First Affiliated Hospital of Chongqing Medical University [PYJJ2019-04]

基金资助正文：This work was supported by grants from the West China Psychiatric Association (2016-19) and the Training Fund of the First Affiliated Hospital of Chongqing Medical University (PYJJ2019-04).