Temporal Variation in Disease Onset and Clinical Features of Lewy Body Disease in China

作者全名："Gan, Jinghuan; Chen, Zhichao; Shi, Zhihong; Li, Xudong; Liu, Shuai; Liu, Yiming; Zhu, Hongcan; Shen, Lu; Zhang, Guili; You, Yong; Guo, Qihao; Zhang, Nan; Lv, Yang; Gang, Baozhi; Yuan, Junliang; Ji, Yong"

作者地址："[Gan, Jinghuan; Li, Xudong; Zhang, Guili; Ji, Yong] Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Dept Neurol, Beijing, Peoples R China; [Chen, Zhichao] Capital Med Univ, Beijing Friendship Hosp, Dept Neurol, Beijing, Peoples R China; [Shi, Zhihong; Liu, Shuai; Ji, Yong] Tianjin Dementia Inst, Tianjin Huanhu Hosp, Dept Neurol, Tianjin Key Lab Cerebrovasc & Neurodegenerat Dis, Tianjin, Peoples R China; [Liu, Yiming] Shandong Univ, Qilu Hosp, Dept Neurol, Shandong, Peoples R China; [Zhu, Hongcan] Zhengzhou Univ, Affiliated Hosp 1, Dept Neurol, Zhengzhou, Henan, Peoples R China; [Shen, Lu] Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha, Hunan, Peoples R China; [You, Yong] Hainan Med Univ, Affiliated Hosp 2, Dept Neurol, Haikou, Hainan, Peoples R China; [Guo, Qihao] Shanghai Jiao Tong Univ Affiliated Sixth Peoples, Dept Gerontol, Shanghai, Peoples R China; [Zhang, Nan] Tianjin Med Univ, Gen Hosp, Dept Neurol, Tianjin, Peoples R China; [Lv, Yang] Chongqing Med Univ, Affiliated Hosp 1, Department Geriat, Chongqing, Peoples R China; [Gang, Baozhi] Harbin Med Univ, Affiliated Hosp 1, Dept Neurol, Harbin, Peoples R China; [Yuan, Junliang] Peking Univ Sixth Hosp, Dept Neurol, Beijing, Peoples R China"

通信作者："Ji, Y (通讯作者)，Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, China Natl Clin Res Ctr Neurol Dis, 119 Nansihuan Xilu, Beijing 100070, Peoples R China.; Ji, Y (通讯作者)，Tianjin Dementia Inst, Tianjin Huanhu Hosp, Dept Neurol, Tian jin Key Lab Cerebrovasc & Neurodegenerat, 6 Jizhao Rd, Tianjin 300350, Peoples R China."

来源：JOURNAL OF ALZHEIMERS DISEASE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000887974500030

JCR分区：Q2

影响因子：4

年份：2022

卷号：90

期号：3

开始页：1263

结束页：1275

文献类型：Article

关键词：Age; Lewy body; mild cognitive impairment; multicenter; Parkinson's disease

摘要："Background: Lewy body dementia is the second most common neurodegenerative dementia, but data concerning the onset age and clinical features in the prodromal stage remain limited in China. Objective: To investigate the associations between onset age and clinical manifestations of cognitive impairment with Lewy bodies in a large-sample cohort. Methods: We included 74 patients with mild cognitive impairment with Lewy bodies (MCI-LB), 533 patients with dementia with Lewy bodies (DLB), 118 patients with Parkinson's disease with MCI (PD-MCI), and 313 patients with Parkinson's disease dementia (PDD) in this multicenter cohort from 22 memory clinics of China from 1 January 2018 to 31 March 2022. The onset age, clinical manifestations, and neuropsychological assessments were recorded and analyzed after reviewing the medical records. Results: The average onset age of memory losswas 68.28 (+/- 7.00) years, and parkinsonism happened 2.00 (+/- 1.24) years later for patients with MCI-LB. The average onset age of parkinsonism was 60.56 (+/- 8.96) years, and the memory loss happened 3.49 (+/- 3.02) years later for patients with PD-MCI. Rapid eye movement sleep behavior disorder and visual hallucinations were frequently reported in MCI-LB, DLB, and PDD, while visual hallucinations were least frequently reported in PD-MCI. Lower scores of MMSE and depression, and higher scores of activities of daily living and delusions, were independently associated with older onset age in DLB. Conclusion: The onset of PD-MCI precedes MCI-LB, and memory loss occurs 3 years after parkinsonism. The onset age is associated with cognition and neuropsychiatric symptoms in process."

基金机构："National Natural Science Foundation of China [82171182, 81571057]; Science and Technology Project of Tianjin Municipal Health Committee [ZC20121, KJ20048]; Tianjin Science and Technology Project [16ZXMJSY00010]; Tianjin Key Medical Discipline (Specialty) Construction Project [TJYXZDXK-052B]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (grant numbers 82171182 and 81571057), Science and Technology Project of Tianjin Municipal Health Committee (grant numbers ZC20121 and KJ20048), the Tianjin Science and Technology Project (grant number 16ZXMJSY00010), and Tianjin Key Medical Discipline (Specialty) Construction Project (grant number: TJYXZDXK-052B)."