Relationship between Yes-Associated Protein 1 and Prognosis of Digestive System Neoplasm: Quantitative Analysis and Bioinformatics Analysis Based on 4023 Patients
作者全名："Yuan Yuan, Luo; Shuai, Wu; Yuan-Peng, Zou; Ting, Jiang; Wei, Xia; Yu-Qin, He"
作者地址："[Yuan Yuan, Luo; Wei, Xia; Yu-Qin, He] Army Med Univ, Daping Hosp, Dept Gastroenterol, Chongqing 400042, Peoples R China; [Yuan Yuan, Luo] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400030, Peoples R China; [Shuai, Wu] Chongqing Med Univ, Dept Gastroenterol Surg, Yong Chuan Hosp, Chongqing 400016, Peoples R China; [Yuan-Peng, Zou; Ting, Jiang] Chongqing Univ, Coll Foreign Languages & Cultures, Chongqing 400030, Peoples R China"
通信作者："Wei, X; Yu-Qin, H (通讯作者)，Army Med Univ, Daping Hosp, Dept Gastroenterol, Chongqing 400042, Peoples R China."
来源：EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ESI学科分类：CLINICAL MEDICINE
WOS号：WOS:000890991400007
JCR分区：Q3
影响因子：2.65
年份：2022
卷号：2022
期号：
开始页：
结束页：
文献类型：Article
关键词：
摘要："Yes-associated protein 1 (YAP1) is involved in the development of a variety of malignancies. However, the prognosis of malignant digestive tumors with YAP1 expression is still controversial. This study searched 31 articles with 36 data sets of 4023 patients to explore the role of YAP1 expression on the prognosis of digestive malignant tumors by searching the PubMed, Embase, Web of Science, Google Scholar, and Cochrane Library databases. Specifically, relevant cancer expression matrix data were downloaded from The Cancer Genome Atlas (TCGA) database. In this meta-analysis, quantitative analysis showed that the overexpression of YAP1 was not conducive to OS (1.62, 95% CI (1.38, 1.90), P=0.001) and DFS (1.59, 95% CI (1.31, 1.93), P=0.001) in patients with digestive malignant tumors. In addition, TCGA database analysis showed that YAP1 was overexpressed in gastric cancer, cholangiocarcinoma, and colorectal cancer. Survival analysis showed that the patients with high expression of YAP1 in pancreatic cancer have a poor OS (MST: 394 vs. 691 days, P < 0.0001) and DFS (MST: 371 vs. 542 days, P=0.026) prognosis. YAP1 may be a molecular marker that effectively predicts the survival of malignant digestive tumors, especially pancreatic cancer, and is a potential therapeutic target for malignant digestive tumors."
基金机构：Natural Science Foundation of China; General Program of Chongqing Natural Science Foundation; Chongqing Science and Health Joint Medical Research Project; Science and Technology Innovation Enhancement Project of Army Medical University; [81700466/H0307]; [cstc2019jcyj-msxmX0384]; [2020MSXM073]; [2019XLC3052]
基金资助正文："AcknowledgmentsThis study was supported by grants from the Natural Science Foundation of China (81700466/H0307), General Program of Chongqing Natural Science Foundation (cstc2019jcyj-msxmX0384), Chongqing Science and Health Joint Medical Research Project (2020MSXM073), and Science and Technology Innovation Enhancement Project of Army Medical University (2019XLC3052)."
