Efficacy of guselkumab compared with adalimumab for psoriasis: a meta-analysis of randomized controlled studies

作者全名："Fu, Hongyi; Guo, Jing"

作者地址："[Fu, Hongyi] Chongqing Med Univ, Dept Med Cosmetol Ctr, Branch 1, Affilliated Hosp 1, Chongqing, Peoples R China; [Guo, Jing] Youyang Peoples Hosp, Dept Dermatol, Chongqing, Peoples R China"

通信作者："Guo, J (通讯作者)，Youyang Peoples Hosp, Dept Dermatol, Chongqing, Peoples R China."

来源：POSTEPY DERMATOLOGII I ALERGOLOGII

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000891776500021

JCR分区：Q4

影响因子：1.4

年份：2022

卷号：39

期号：5

开始页：953

结束页：958

文献类型：Article

关键词：guselkumab; adalimumab; psoriasis; efficacy; randomized controlled trials

摘要："Introduction: The efficacy of guselkumab versus adalimumab for psoriasis remains controversial. Aim: We conducted a systematic review and meta-analysis to explore the influence of guselkumab versus adalim-umab on treatment efficacy for psoriasis. Material and methods: We have searched PubMed, Embase, Web of Science, EBSCO, and Cochrane library data-bases for randomized controlled trials (RCTs) published until March 2021 and assessing the efficacy and safety of guselkumab versus adalimumab for psoriasis. This meta-analysis was performed using the random-effects model. Results: Three RCTs were included in the meta-analysis. Overall, compared with adalimumab for psoriasis, gusel-kumab was associated with improved PASI 100 (OR = 2.18; 95% CI: 1.47 to 3.23; p = 0.0001), PASI 90 (OR = 2.63; 95% CI: 2.11 to 3.27; p < 0.00001), PASI 75 (OR = 3.10; 95% CI: 2.35 to 4.08; p < 0.00001) and PGA 0/1 (OR = 2.04; 95% CI: 1.26 to 3.31; p = 0.004), as well as decreased DLQI (SMD = -0.24; 95% CI: -0.34 to -0.13; p < 0.00001). In addition, gusel-kumab resulted in higher DLQI score 0/1 (OR = 1.88; 95% CI: 1.51 to 2.33; p < 0.00001) than adalimumab. Conclusions: Guselkumab showed better efficacy than adalimumab for psoriasis."

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