Quantitative muscle ultrasound in children with Duchenne muscular dystrophy: Comparing to magnetic resonance imaging

作者全名："Hu, Jun; Jiang, Li; Hong, Siqi; Cheng, Li; Wang, Qiao; Peng, Xuehua; Qin, Jiaqiang; Zou, Lin"

作者地址："[Hu, Jun] Fujian Med Univ, Dept Pediat, Union Hosp, Fuzhou, Peoples R China; [Jiang, Li; Hong, Siqi; Cheng, Li; Wang, Qiao; Peng, Xuehua; Qin, Jiaqiang; Zou, Lin] Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China; [Jiang, Li; Hong, Siqi; Cheng, Li; Wang, Qiao; Peng, Xuehua; Qin, Jiaqiang; Zou, Lin] Key Lab Pediat Chongqing, Chongqing, Peoples R China; [Jiang, Li; Hong, Siqi; Cheng, Li; Wang, Qiao; Peng, Xuehua; Qin, Jiaqiang; Zou, Lin] Technol Cooperat Ctr Child Dev & Disorders, Chongqing Int Sci, Chongqing, Peoples R China; [Jiang, Li; Hong, Siqi] Chongqing Med Univ, Childrens Hosp, Dept Neurol, Chongqing, Peoples R China; [Wang, Qiao] Chongqing Med Univ, Childrens Hosp, Dept Ultrasound, Chongqing, Peoples R China; [Peng, Xuehua] Chongqing Med Univ, Childrens Hosp, Dept Radiol, Chongqing, Peoples R China; [Qin, Jiaqiang] Chongqing Med Univ, Childrens Hosp, Dept Orthoped, Chongqing, Peoples R China; [Zou, Lin] Chongqing Med Univ, Childrens Hosp, Mol Med Ctr, Chongqing, Peoples R China; [Hu, Jun] Fujian Med Univ, Dept Pediat, Union Hosp, 29 Xinquan Rd, Fuzhou 350001, Peoples R China"

通信作者："Hu, J (通讯作者)，Fujian Med Univ, Dept Pediat, Union Hosp, 29 Xinquan Rd, Fuzhou 350001, Peoples R China."

来源：JOURNAL OF CLINICAL ULTRASOUND

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000892598700001

JCR分区：Q3

影响因子：1.2

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：child; Duchenne muscular dystrophy; magnetic resonance imaging; quantitative muscle ultrasound

摘要："Objective: There is a need today for favorable biomarkers to follow up on the disease progression and therapeutic response in patients with Duchenne muscular dystrophy (DMD). This study evaluates whether quantitative muscle ultrasound (QMUS) or magnetic resonance imaging (MRI) is more suitable for the assessment of DMD in China. Methods: Thirty-six boys with DMD, who were treated with prednisone from baseline to month 12, were enrolled in this longitudinal, observational cohort study. Muscle thickness and echo intensity on QMUS and T1-weighted MRI grading were measured in the right rectus femoris. Results: Scores for muscle thickness and echo intensity in QMUS and T1-weighted MRI grading showed significant correlations with the clinical characteristics of muscle strength, timed testing, and quality of life (p < 0.05). Scores for muscle thickness and echo intensity on QMUS also showed good correlations with T1-weighted MRI grading (p < 0.05). However, 15 of 36 boys with DMD did not undergo MRI examinations for various reasons. Conclusions: QMUS and MRI can be used as biomarkers for tracking DMD to some extent. Both have strengths and weaknesses and the specific needs and goals of the clinical or research project are what make one preferable to the other."

基金机构："Medical Innovation Project of Fujian Province; Research Project of Chongqing Municipal Health Bureau [2014-CX-17]; Research Project of Joint Funds for the Innovation of Science and Technology, Fujian Province [2012-1-044]; [2018Y9029]"

基金资助正文："Medical Innovation Project of Fujian Province, Grant/Award Number: 2014-CX-17; Research Project of Chongqing Municipal Health Bureau, Grant/Award Number: 2012-1-044; Research Project of Joint Funds for the Innovation of Science and Technology, Fujian Province, Grant/Award Number: 2018Y9029"