ASSESSMENT OF GLOBAL CARDIAC FUNCTION USING AUTOSTRAIN AUTOMATIC STRAIN QUANTITATIVE TECHNOLOGY IN PATIENTS WITH BREAST CANCER UNDERGOING ANTHRACYCLINE-BASED CHEMOTHERAPY

作者全名："Gu, Jin; Wang, Dong; Jiang, Lan; Huang, Yuan; Ding, Lunbi; Chen, Xueying; He, Yiman; Zhou, Zefen; Pu, Darong"

作者地址："[Gu, Jin; Wang, Dong; Jiang, Lan; Huang, Yuan; Chen, Xueying; He, Yiman; Zhou, Zefen; Pu, Darong] Chongqing Med Univ, Dept Ultrasound, Affiliated Hosp 1, Chongqing, Peoples R China; [Gu, Jin; Huang, Yuan; Ding, Lunbi; Zhou, Zefen] Chongqing Publ Hlth Med Ctr, Dept Ultrasound, Chongqing, Peoples R China; [Pu, Darong] Chongqing Med Univ, Dept Ultrasound, Affiliated Hosp 1, Youyi Rd 1, Chongqing 400016, Peoples R China"

通信作者："Pu, DR (通讯作者)，Chongqing Med Univ, Dept Ultrasound, Affiliated Hosp 1, Youyi Rd 1, Chongqing 400016, Peoples R China."

来源：ULTRASOUND IN MEDICINE AND BIOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000893118700001

JCR分区：Q2

影响因子：2.4

年份：2023

卷号：49

期号：1

开始页：368

结束页：374

文献类型：Article

关键词：Cardiotoxicity; Speckle tracking; Left ventricle; Right ventricle; Left atrium

摘要："In patients with breast cancer undergoing anthracycline-based chemotherapy, we investigated the deformational parameters of the left ventricle, right ventricle and left atrium, as well as the relationship between these parameters. Ninety-five patients with breast cancer who were treated with anthracycline-based chemother-apy were enrolled. The control group included 116 healthy female volunteers. Parameters including left ventricu-lar global longitudinal strain (LV-GLS); right ventricular free wall longitudinal strain (RVFWSL) and global longitudinal strain (RV4CSL); and peak strain of the left atrium during LV systole (LASR), early LV diastole (LASCD) and late LV diastole (LASCT) were analyzed by speckle tacking echocardiography. LV-GLS, LASR, LASCD, RVFWSL and RV4CSL in the chemotherapy group decreased significantly by 15.6%, 13.8%, 19.8%, 21.8% and 13.2% (p < 0.05), respectively, when compared with the control group. LASCT was slightly increased in the chemotherapy group but the increase was not statistically significant (p > 0.05). Formulas for the influenc-ing factors of LV-GLS were LV-GLS = -18.73738541 + 0.13961 x LVIDd + 0.09672 x LASCD + 0.18113 x RVFWSL in the control group and LV-GLS = -8.026302253 + 0.20811 x LASCD + 0.11084 x LASCT + 0.12153 x RVFWSL in the chemotherapy group. Both LV contraction and RV contraction were impaired after the completion of anthracycline-based therapy, and RVFWSL may be superior to LV-GLS in assessing cardio-toxicity. LA reserve and channel function were significantly reduced, while pump function was slightly increased. Compared with the results among healthy people, the influencing factor of LV-GLS varied after anthracycline treatment, and LA function had a greater impact on LV-GLS. (E-mail: doc_pdr@sina.com) (c) 2022 Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine & Biology."

基金机构：Science and Technology Bureau [2019ZDXM033]; Chongqing Medical Scientific Research Project; Chongqing Health Commission

基金资助正文："The work described here was supported by the Chongqing Medical Scientific Research Project, a joint project of the Chongqing Health Commission and the Science and Technology Bureau (2019ZDXM033) ."