The impact of obesity epidemic on type 2 diabetes in children and adolescents: A systematic review and meta-analysis
作者全名："He, Qing-Xia; Zhao, Li; Tong, Ji-Shuang; Liang, Xiao-Yue; Li, Ri-Na; Zhang, Ping; Liang, Xiao-Hua"
作者地址："[He, Qing-Xia] Hosp Shimian Cty, Yaan, Peoples R China; [Zhao, Li; Tong, Ji-Shuang; Liang, Xiao-Yue; Li, Ri-Na; Zhang, Ping; Liang, Xiao-Hua] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Clin Epidemiol & Biostat, Chongqing Key Lab Child Hlth & Nutr,Minist Educ,Ke, Chongqing 400016, Peoples R China; [Liang, Xiao-Yue] Harbin Med Univ, Dept Humanities & Social Sci, Daqing Campus, Daqing 163319, Heilongjiang, Peoples R China; [Liang, Xiao-Hua] Clin Epidemiol & Biostat Dept, 136 2nd Zhongshan Rd, Chongqing 400014, Peoples R China"
通信作者："Liang, XH (通讯作者)，Clin Epidemiol & Biostat Dept, 136 2nd Zhongshan Rd, Chongqing 400014, Peoples R China."
来源：PRIMARY CARE DIABETES
ESI学科分类：CLINICAL MEDICINE
WOS号：WOS:000898485200002
JCR分区：Q2
影响因子：2.9
年份：2022
卷号：16
期号：6
开始页：736
结束页：744
文献类型：Review
关键词：Obesity; Type 2 diabetes; Prediabetes; Fasting blood glucose; Insulin; HOMA-IR
摘要："Aim: To assess the impact of the obesity epidemic on type 2 diabetes (T2D), prediabetes and glycometabolic indices in children and adolescents. Methods: We searched four electronic databases (PubMed, Embase, Cochrane and Web of Science). Cross-sectional or cohort studies that reported on obesity and the prevalence of T2D or prediabetes in children and adolescents were reviewed. The study design, sample size and clinical outcomes were extracted from each study. The prevalence of T2D and prediabetes from the studies were pooled using meta-analysis methods. Results: Meta-analysis of 228184 participants showed that the prevalence of T2D was 1.3% (95% confidence interval (CI), 0.6-2.1%) in obese subjects, which was 13 times that in normal weight subjects (0.1%, 95% CI, 0.01-0.2%). The prevalence of prediabetes in obese subjects was 3 times that in normal subjects at 17.0% (13.0-22.0%) vs. 6.0% (0.01-11.0%). Moreover, BMI was positively correlated with the prevalence of T2D, prediabetes and glycometabolic indices in obese children and adolescents. Conclusion: The pooled results confirm that obesity in children and adolescents leads to statistically significant increases in the prevalence of T2D and prediabetes and in glycometabolic indicator levels."
基金机构：Major Health Project of Chongqing Science and Technology Bureau [CSTC2021jscx-gksb-N0001]; Program for Youth Innovation in Future Medicine Chongqing Medical University [W0088]; Intelligent Medicine Research Project of Chongqing Medical University [ZHYX202109]; Ministry of Science and Technology of the People's Republic of China [2017YFC0211705]; National Natural Science Foundation of China [81502826]; Education Commission of Chongqing [KJQN201900443]; China Postdoctoral Science Foundation [2014M562289]
基金资助正文："The authors would like to acknowledge the laboratory support of the Ministry of Education Key Laboratory of Child Development and Dis-orders. This work was supported by the Major Health Project of Chongqing Science and Technology Bureau (Grant no. CSTC2021jscx-gksb-N0001) , the Program for Youth Innovation in Future Medicine Chongqing Medical University (Grant no. W0088) , the Intelligent Medicine Research Project of Chongqing Medical University (Grant no. ZHYX202109) , the Ministry of Science and Technology of the People's Republic of China (Grant no. 2017YFC0211705) ; the National Natural Science Foundation of China (Grant no. 81502826) ; the Education Commission of Chongqing (Grant no. KJQN201900443) ; the China Postdoctoral Science Foundation (Grant no. 2014M562289) . The funders had no role in the study design, the data collection and analysis, the decision to publish, or the preparation of the manuscript."
