"The impact of hyperglycaemic crisis episodes on long-term outcomes for inpatients presenting with acute organ injury: A prospective, multicentre follow-up study"

作者全名："Duan, Zixiao; Song, Peiyang; Yang, Cheng; Deng, Liling; Jiang, Youzhao; Deng, Fang; Jiang, Xiaoyan; Chen, Yan; Yang, Gangyi; Ma, Yu; Deng, Wuquan"

作者地址："[Duan, Zixiao; Song, Peiyang; Yang, Cheng; Deng, Liling; Jiang, Xiaoyan; Chen, Yan; Ma, Yu; Deng, Wuquan] Chongqing Univ Cent Hosp, Chongqing Emergency Med Ctr, Dept Endocrinol, Chongqing, Peoples R China; [Duan, Zixiao; Yang, Gangyi] Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol, Chongqing, Peoples R China; [Jiang, Youzhao] Banan Peoples Hosp Chongqing, Dept Endocrinol, Chongqing, Peoples R China; [Deng, Fang] Chongqing Southwest Hosp, Dept Endocrinol, Chongqing, Peoples R China"

通信作者："Deng, WQ (通讯作者)，Chongqing Univ Cent Hosp, Chongqing Emergency Med Ctr, Dept Endocrinol, Chongqing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000899636300001

JCR分区：Q1

影响因子：5.2

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：diabetes; hyperglycaemic crisis episode; acute organ injury; mortality; long-term prognosis

摘要："BackgroundThe long-term clinical outcome of poor prognosis in patients with diabetic hyperglycaemic crisis episodes (HCE) remains unknown, which may be related to acute organ injury (AOI) and its continuous damage after hospital discharge. This study aimed to observe the clinical differences and relevant risk factors in HCE with or without AOI. MethodsA total of 339 inpatients were divided into an AOI group (n=69) and a non-AOI group (n=270), and their differences and risk factors were explored. The differences in clinical outcomes and prediction models for evaluating the long-term adverse events after hospital discharge were established. ResultsThe mortality among cases complicated by AOI was significantly higher than that among patients without AOI [8 (11.59%) vs. 11 (4.07%), Q = 0.034] during hospitalization. After a 2-year follow-up, the mortality was also significantly higher in patients with concomitant AOI than in patients without AOI after hospital discharge during follow-up [13 (21.31%) vs. 15 (5.8%), Q < 0.001]. The long-term adverse events in patients with concomitant AOI were significantly higher than those in patients without AOI during follow-up [15 (24.59%) vs. 31 (11.97%), Q = 0.015]. Furthermore, Blood beta-hydroxybutyric acid (P = 0.003), Cystatin C (P <0.001), serum potassium levels (P = 0.001) were significantly associated with long-term adverse events after hospital discharge. ConclusionsThe long-term prognosis of HCE patients complicated with AOI was significantly worse than that of HCE patients without AOI. The laboratory indicators were closely correlated with AOI, and future studies should explore the improvement of clinical outcome in response to timely interventions."

基金机构：Joint Medical Research Programs of Chongqing Science and Technology Bureau and Health Commission Foundation; Fundamental Research Funds for the Central Universities [2021CDJYGRH-012]; fund of Sichuan Provincial Western Psychiatric Association's CSPC LEADING Scientific Research Project [WL2021002]

基金资助正文：This study was supported by the Joint Medical Research Programs of Chongqing Science and Technology Bureau and Health Commission Foundation awarded to Dr. Wuquan Deng in 2023. The Fundamental Research Funds for the Central Universities (2021CDJYGRH-012) and the fund of Sichuan Provincial Western Psychiatric Association's CSPC LEADING Scientific Research Project (Grant No. WL2021002) awarded to WD.