High consumption of whole grain foods decreases the risk of dementia and Alzheimer's disease: Framingham Offspring Cohort

作者全名："Wang, Kanran; Tang, Weimin; Hao, Xingchen; Liu, Hong"

作者地址："[Wang, Kanran; Tang, Weimin] Brigham & Womens Hosp, Dept Anesthesiol Perioperat & Pain Med, Boston, MA 02115 USA; [Wang, Kanran; Tang, Weimin] Harvard Med Sch, Boston, MA 02115 USA; [Wang, Kanran] Brigham & Womens Hosp, Cognit Outcomes Geriatr Surg COGS Res Ctr, Boston, MA 02115 USA; [Wang, Kanran] Chongqing Med Univ, Dept Endocrinol, Affiliated Hosp 1, Chongqing, Peoples R China; [Hao, Xingchen] Harvard T H Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA; [Liu, Hong] Chongqing Med Univ, Ctr Med Reprod, Affiliated Hosp 1, Chongqing, Peoples R China"

通信作者："Wang, KR (通讯作者)，Brigham & Womens Hosp, Dept Anesthesiol Perioperat & Pain Med, Boston, MA 02115 USA.; Wang, KR (通讯作者)，Harvard Med Sch, Boston, MA 02115 USA.; Wang, KR (通讯作者)，Brigham & Womens Hosp, Cognit Outcomes Geriatr Surg COGS Res Ctr, Boston, MA 02115 USA.; Wang, KR (通讯作者)，Chongqing Med Univ, Dept Endocrinol, Affiliated Hosp 1, Chongqing, Peoples R China.; Liu, H (通讯作者)，Chongqing Med Univ, Ctr Med Reprod, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：PSYCHIATRY AND CLINICAL NEUROSCIENCES

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000901693500001

JCR分区：Q1

影响因子：5

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Alzheimer's disease; dementia; Framingham heart study Offspring Cohort; population-based; whole grain foods

摘要："AimsTo examine the longitudinal associations between total and individual whole grain (WG) food intake and the risk of all-cause dementia and Alzheimer's disease (AD) dementia.MethodsThis study included 2958 subjects (mean age at baseline was 61 & PLUSMN; 9 years) from the Framingham Offspring Cohort. Standardized interviews, physician examinations, and laboratory tests were collected approximately every 4 years, and the Food Frequency Questionnaire (FFQ) was conducted in cycle 5. Proportional hazards models and cubic spline regression examined associations between WG foods and all-cause dementia and AD dementia.ResultsOver an average of 12.6 years of follow-up, there were 322 dementia cases, of which 247 were AD dementia. After multivariate and dietary adjustments, individuals with the highest category for total WG food consumption had a lower risk of all-cause dementia [HR 0.66, 95% confidence interval (CI) 0.51-0.81] and AD dementia (HR 0.60, 95% CI 0.46-0.78) than individuals with the lowest category. The results remained comparable in different subgroups stratifying for age, sex, education, body mass index, and smoking status without significant interaction. Moreover, these inverse associations were seen for most individual WG foods except popcorn. A nonlinear dose-response association was shown between total WG intake and all-cause dementia and AD dementia, where the rate reduction slightly plateaued at more than one and two servings/day, respectively.ConclusionsHigher consumption of total and several common individual WG foods was strongly associated with a lower risk of all-cause dementia and AD dementia."

基金机构：Chongqing Medical University Scholarship Fund for Development of Young Talents; [XRJH201901]

基金资助正文：Chongqing Medical University Scholarship Fund for Development of Young Talents (XRJH201901) to Kanran Wang