A double-cavity nor-seco-cucurbit[10]uril-based fluorescent probe for detection of ClO- and its application in cell imaging

作者全名："Cen, Ran; Liu, Ming; Xiao, Han; Yang, Hai-Ping; Chen, Li-Xia; Li, Qiu; Wang, Cheng-Hui; Tao, Zhu; Xiao, Xin"

作者地址："[Cen, Ran; Liu, Ming; Chen, Li-Xia; Wang, Cheng-Hui; Tao, Zhu; Xiao, Xin] Guizhou Univ, Sch Chem & Chem Engn, Key Lab Macrocycl & Supramol Chem Guizhou Prov, Guiyang 550025, Peoples R China; [Xiao, Han; Yang, Hai-Ping; Li, Qiu] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ Key Lab Child Dev & Disorders, Dept Nephrol,Childrens Hosp,Chongqing Key Lab Pedi, Chongqing 400014, Peoples R China"

通信作者："Xiao, X (通讯作者)，Guizhou Univ, Sch Chem & Chem Engn, Key Lab Macrocycl & Supramol Chem Guizhou Prov, Guiyang 550025, Peoples R China.; Yang, HP; Li, Q (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ Key Lab Child Dev & Disorders, Dept Nephrol,Childrens Hosp,Chongqing Key Lab Pedi, Chongqing 400014, Peoples R China."

来源：SENSORS AND ACTUATORS B-CHEMICAL

ESI学科分类：CHEMISTRY

WOS号：WOS:000904672700005

JCR分区：Q1

影响因子：8

年份：2023

卷号：378

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：nor-seco-cucurbit[10]uril; Host-guest interaction; Fluorescent probe; ClO-Cell imaging

摘要："A supramolecular fluorescent probe based on double-cavity nor-seco-cucurbit[10]uril (ns-Q[10]) was constructed using the non-covalent host-guest interactions between ns-Q[10] and positively charged Astrazon Pink FG (APFG). The intramolecular charge transfer (ICT) effect induces the APFG@ns-Q[10] probe to emit strong orange-red fluorescence. APFG@ns-Q[10] exhibits desirable optical properties and low toxicity, and has been successfully applied to the imaging of HK2 and HeLa cells. When APFG@ns-Q[10] interacts with ClO-, the C--C double bond in APFG is oxidized and the molecule is cleaved, which leads to the fluorescence is quenched. The specificity and sensitivity of APFG@ns-Q[10] to ClO- allows it to be used for the detection and tracking of ClO- in cells. APFG@ns-Q[10] demonstrates good biocompatibility, which is an excellent foundation for its application in cell imaging."

基金机构："National Natural Science Foundation of China [21871064]; Innovation Program for High-level Talents of Guizhou Province [2016-5657]; Program for Youth Innovation in Future Medicine, Chongqing Medical University [W0098]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (21871064) , the Innovation Program for High-level Talents of Guizhou Province (2016-5657) and Program for Youth Innovation in Future Medicine, Chongqing Medical University (No. W0098) ."