Well-controlled gestational diabetes mellitus without pharmacologic therapy decelerates weight gain in infancy

作者全名："Li, Chao; Cai, Yixi; Li, Yinying; Peng, Bin; Liu, Yongfang; Wang, Zhenming; Yang, Ting; Hu, Yirong; Fu, Yajun; Shi, Tingmei; Peng, Hong; Zhang, Yue; Chen, Jie; Li, Tingyu; Chen, Li"

作者地址："[Li, Chao; Liu, Yongfang; Yang, Ting; Chen, Jie; Li, Tingyu; Chen, Li] Chongqing Med Univ, Dept Growth Dev & Mental Hlth Children, Key Lab Child Dev & Disorders, Childrens Hosp,Minist Educ, Chongqing, Peoples R China; [Li, Chao; Liu, Yongfang; Yang, Ting; Chen, Jie; Li, Tingyu; Chen, Li] Chongqing Med Univ, Adolescence Ctr, Natl Clin Res Ctr Child Hlth & Disorders, China Int Sci & Technol Cooperat Base Child Dev &, Chongqing, Peoples R China; [Li, Chao; Liu, Yongfang; Yang, Ting; Chen, Jie; Li, Tingyu; Chen, Li] Chongqing Key Lab Child Hlth & Nutr, Chongqing, Peoples R China; [Li, Chao; Cai, Yixi; Li, Yinying; Wang, Zhenming; Hu, Yirong; Fu, Yajun; Shi, Tingmei; Peng, Hong; Zhang, Yue] First Peoples Hosp Chongqing Liangjiang New Area, Dept Child Hlth Care, Chongqing, Peoples R China; [Peng, Bin] Chongqing Med Univ, Sch Publ Hlth & Management, Dept Hlth Stat, Chongqing, Peoples R China"

通信作者："Chen, L (通讯作者)，Chongqing Med Univ, Dept Growth Dev & Mental Hlth Children, Key Lab Child Dev & Disorders, Childrens Hosp,Minist Educ, Chongqing, Peoples R China.; Chen, L (通讯作者)，Chongqing Med Univ, Adolescence Ctr, Natl Clin Res Ctr Child Hlth & Disorders, China Int Sci & Technol Cooperat Base Child Dev &, Chongqing, Peoples R China.; Chen, L (通讯作者)，Chongqing Key Lab Child Hlth & Nutr, Chongqing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000905302200001

JCR分区：Q1

影响因子：5.2

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：gestational diabetes mellitus; growth; offspring; lifestyle management; glucose control

摘要："AimThere are no prospective longitudinal studies on the association between well-controlled gestational diabetes mellitus (GDM) without pharmacologic therapy and the physical growth of offspring in infancy. We aimed to identify the trajectories in physical growth (from 0-12 months of age) in the offspring of mothers with well-controlled GDM without pharmacologic therapy in a prospective cohort in China. MethodsThis study included 236 offspring of mothers with GDM and 369 offspring of mothers without GDM. Mothers with GDM were not on pharmacologic therapy. The length and weight of infants were measured at 0, 1, 3, 6, and 12 months. Linear mixed-effect models and linear mixed-effect models were applied. ResultsThe fully adjusted model showed that the weight-for-age z-score (WAZ), length-for-age z-score (LAZ), and BMI-for-age z-score (BMIZ) were similar at birth for the GDM and control groups. However, subsequent increases in WAZ and BMIZ for the GDM group lagged the increases for the control group at the subsequent periods of observation, 0-1, 0-6, and 0-12 months. ConclusionsWell-controlled GDM without pharmacologic therapy may normalize physical growth of offspring at birth and decelerate their weight gain in infancy. Whether glycemic control can mitigate the long-term effects of GDM on the growth trajectory in offspring remains unclear."

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