Effect of interval between oocyte retrieval and resuscitation embryo transfer on pregnancy outcomes

作者全名："Wan, Qi; Chen, Ming-Xing; Wang, Xuejiao; Tan, Li; Yu, Hui-Jun; Lv, Xing-Yu; Zhong, Zhao-Hui; Tang, Xiao-Jun; Ding, Yu-Bin; Xia, Min; Li, Yuan"

作者地址："[Wan, Qi; Wang, Xuejiao; Tan, Li; Yu, Hui-Jun; Lv, Xing-Yu; Li, Yuan] Chengdu Jinjiang Hosp Womens & Childrens Hlth, Reprod Ctr, Chengdu, Sichuan, Peoples R China; [Wan, Qi] Sichuan Univ, West China Hosp 2, Dept Obstet & Gynecol, Chengdu, Peoples R China; [Wan, Qi] Sichuan Univ, Minist Educ, Key Lab Birth Defects & Related Dis Women & Childr, Chengdu, Peoples R China; [Chen, Ming-Xing; Ding, Yu-Bin] Chongqing Med Univ, Minist Educ China, Sch Publ Hlth, Joint Int Res Lab Reprod & Dev, Chongqing, Peoples R China; [Zhong, Zhao-Hui; Tang, Xiao-Jun] Chongqing Med Univ, Res Ctr Med & Social Dev, Innovat Ctr Social Risk Governance Hlth, Sch Publ Hlth,Dept Epidemiol, Chongqing, Peoples R China; [Xia, Min] Chongqing Hosp Tradit Chinese Med, Dept Gynecol, Chongqing, Peoples R China"

通信作者："Li, Y (通讯作者)，Chengdu Jinjiang Hosp Womens & Childrens Hlth, Reprod Ctr, Chengdu, Sichuan, Peoples R China.; Xia, M (通讯作者)，Chongqing Hosp Tradit Chinese Med, Dept Gynecol, Chongqing, Peoples R China."

来源：FRONTIERS IN MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000913321000001

JCR分区：Q1

影响因子：3.1

年份：2023

卷号：9

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：immediate frozen embryo transfer; delayed frozen embryo transfer; live birth rate; clinical pregnancy; pregnancy outcome

摘要："ObjectivesResuscitation transfer of embryos after elective cryopreservation has been widely applied in in vitro fertilization-embryo transfer (IVF-ET) therapy for human infertility or sterility owing to higher embryo implantation rates. This method separates oocyte retrieval from embryo transfer. The optimal time for frozen embryo transfer (FET) remains unknown. Therefore, this study mainly compares the advantages and disadvantages of delayed FET and immediate FET through retrospective analysis. MethodsWe analyzed real world data of patients who underwent resuscitation transplantation between October 2019 and July 2021 at the Reproductive Center of Chengdu Jinjiang Hospital for Women's and Children's Health. Propensity score matching was applied to control potential confounding factors. A total of 5,549 patients who received at least one FET were analyzed. Patients undergoing transplantation within 60 days of oocyte retrieval were included in the immediate FET group (n = 1,265) and those undergoing transplantation > 60 days after retrieval were included in the delayed FET group (n = 4,284). ResultsLive birth rates between the two groups were comparable (45.25% vs. 45.76%, p = 0.757). Moreover, no difference was observed in the rates of biochemical pregnancy (64.50% vs. 66.80%), clinical pregnancy (55.24% vs. 56.83%), ectopic pregnancy (1.47% vs. 1.39%), early miscarriage (14.41% vs. 16.20%), late miscarriage (2.21% vs. 2.09%), singleton premature delivery (16.67% vs. 18.29%), and neonatal deformity (1.97% vs. 1.80%). After stratifying the patients based on the type of embryo transferred, number of embryos transferred, FET protocol, and good prognosis criteria, live birth rates remained comparable between the two groups (p > 0.05). ConclusionPregnancy outcomes were comparable between the immediate and delayed FET groups."

基金机构："Medical Science and Technology Project of Sichuan Provincial Health Committee [21PJ166]; Natural Science Foundation of Chongqing [cstc2019jcyj-msxmX0749, cstc2019jxjl130030, cstc2018jxjl130065]"

基金资助正文："Funding This study was funded by the Medical Science and Technology Project of Sichuan Provincial Health Committee (21PJ166) and supported by the grants from Natural Science Foundation of Chongqing (Nos. cstc2019jcyj-msxmX0749, cstc2019jxjl130030, and cstc2018jxjl130065)."