Coronary artery disease in a patient with Addison's disease: a case report and literature review

作者全名："Zhao, Ruohan; Luo, Suxin; Wang, Shuzhen; Wen, Yi; Xiong, Feng"

作者地址："[Zhao, Ruohan; Wang, Shuzhen; Xiong, Feng] Southwest Jiaotong Univ, Affiliated Hosp, Chengdu Peoples Hosp 3, Dept Cardiol,Cardiovasc Inst, Chengdu 610031, Peoples R China; [Luo, Suxin] Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, Chongqing 400016, Peoples R China; [Wen, Yi] Chongqing Med Univ, Univ Town Hosp, Hlth Management Ctr, Chongqing 401331, Peoples R China"

通信作者："Xiong, F (通讯作者)，Southwest Jiaotong Univ, Affiliated Hosp, Chengdu Peoples Hosp 3, Dept Cardiol,Cardiovasc Inst, Chengdu 610031, Peoples R China."

来源：BMC CARDIOVASCULAR DISORDERS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000918723400001

JCR分区：Q3

影响因子：2

年份：2023

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Addison's disease; Adrenal tuberculosis; Unstable angina; Coronary artery disease; Case report

摘要："BackgroundAddison's disease which is due to dysfunction of the adrenal gland, with abnormal secretion of glucocorticoids and mineralocorticoids, is rare. By inducing inflammation and disorders of water and electrolyte metabolism, Addison's disease may accelerate progression of co-existed cardiovascular diseases. Addison's disease combined with cardiovascular disease is infrequent, only 10 cases in the literature.Case presentationWe reported a 51-year-old male patient with unstable angina pectoris and hypotension. Changes on coronary angiography within 2 years suggested rapid progression of coronary artery disease in a patient with low cardiovascular risk. An additional clue of skin hyperpigmentation, fatigue and further examination confirmed the diagnosis of Addison's disease caused by adrenal tuberculosis. After hormone replacement treatment, the frequency and severity of the angina pectoris were alleviated significantly, as were hypotension, hyperpigmentation and fatigue.ConclusionsThe combination of Addison's disease and coronary artery disease in one patient is rare. Addison's disease can induce inflammation and disorders of water and electrolyte metabolism, which may further accelerate the course of coronary artery disease. Meanwhile, the hypotension in Addison's disease may affect the coronary blood flow, which may result in an increased susceptibility to unstable angina in the presence of coronary stenosis. So, we should analyze comprehensively if the coronary artery disease progress rapidly."

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