Site-specific nanomodulator capable of modulation apoptosis for enhanced colorectal cancer chemo-photothermal therapy

作者全名："Wang, Shuqi; Zhou, Li; Tian, Hailong; Li, Bowen; Su, Miao; Li, Qiong; Nice, Edouard C.; Huang, Canhua; Shao, Jichun; He, Tao"

作者地址："[Wang, Shuqi; He, Tao] Southwest Med Univ, Inst Canc Med, Sch Basic Med Sci, Luzhou 646000, Sichuan, Peoples R China; [Tian, Hailong; Li, Bowen; Su, Miao; Li, Qiong; Huang, Canhua] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R China; [Tian, Hailong; Li, Bowen; Su, Miao; Li, Qiong; Huang, Canhua] Sichuan Univ, West China Hosp, Canc Ctr, Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R China; [Tian, Hailong; Li, Bowen; Su, Miao; Li, Qiong; Huang, Canhua] Sichuan Univ, Collaborat Innovat Ctr Biotherapy, Sch Basic Med Sci & Forens Med, Chengdu 610041, Peoples R China; [Nice, Edouard C.] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia; [Shao, Jichun] Chengdu Med Coll, China Natl Nucl Corp 416 Hosp, Affiliated Hosp 2, Chengdu 610051, Sichuan, Peoples R China; [Zhou, Li] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minist, Chongqing 400016, Peoples R China"

通信作者："He, T (通讯作者)，Southwest Med Univ, Inst Canc Med, Sch Basic Med Sci, Luzhou 646000, Sichuan, Peoples R China.; Shao, JC (通讯作者)，Chengdu Med Coll, China Natl Nucl Corp 416 Hosp, Affiliated Hosp 2, Chengdu 610051, Sichuan, Peoples R China."

来源：JOURNAL OF NANOBIOTECHNOLOGY

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000920479700002

JCR分区：Q1

影响因子：10.6

年份：2023

卷号：21

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Colorectal cancer; Celastrol; IR820; Chemotherapy; Photothermal therapy

摘要："BackgroundColorectal cancer (CRC) is a common malignancy with the second highest mortality and the third highest morbidity worldwide. However, the overall survival of patients is unsatisfactory, thus requiring more effective clinical strategies. Celastrol (CLT), a natural bioactive compound, has been reported to induce reactive oxygen species (ROS)-mediated apoptosis to exhibit significant antitumor effects against CRC. However, the poor water solubility, low targeting ability, and bioavailability of CLT have limited its application, and CLT-induced protective autophagy weakens its therapeutic efficiency.ResultsWe designed a targeted chemo-phototherapy nanoplatform (HCR NPs) to improve the application of CLT. The codelivery of IR820 and CLT in HCR NPs solved the water-soluble problem of CLT and enhanced apoptosis via IR820-mediated hyperthermia. In addition, hydroxychloroquine (HCQ) conjugated to hyaluronic acid (HA) not only increased the active targeting of HCR NPs but also inhibited CLT-induced protective autophagy to exacerbate apoptosis, thus achieving an amplified antitumor effect. Importantly, the HCR NPs exhibited an excellent therapeutic effect on CRC both in vitro and in vivo.ConclusionThe HCR NPs presented in this study may not merely provide a new reference for the clinical application of CLT but also result in an attractive strategy for CRC treatment."

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