The Role of NLRP3 Inflammasome in IgA Nephropathy

作者全名："Wu, Xiaofang; Zhao, Lei; Li, Kailong; Yang, Jurong"

作者地址："[Wu, Xiaofang; Zhao, Lei; Li, Kailong; Yang, Jurong] Chongqing Med Univ, Affiliated Hosp 3, Dept Nephrol, Chongqing 400120, Peoples R China"

通信作者："Yang, JR (通讯作者)，Chongqing Med Univ, Affiliated Hosp 3, Dept Nephrol, Chongqing 400120, Peoples R China."

来源：MEDICINA-LITHUANIA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000921214100001

JCR分区：Q1

影响因子：2.4

年份：2023

卷号：59

期号：1

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结束页：　

文献类型：Review

关键词：autophagy; exosomes; IgA nephropathy; NF-kappa B; NLRP3 inflammasome; ROS

摘要："Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease worldwide today. The NLRP3 inflammasome is a polyprotein complex and an important participant in inflammation. Accumulating studies have shown that the NLRP3 inflammasome participates in a variety of kidney diseases, including IgAN. This review focuses on the role of the NLRP3 inflammasome in IgAN and summarizes multiple involved pathways, which may provide novel treatments for IgAN treatment."

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