Neoadjuvant chemotherapy in advanced epithelial ovarian cancer by histology: A SEER based survival analysis

作者全名："Liu, Yuexi; Ni, Meng; Huang, Fanfan; Gu, Qiuying; Xiao, Yao; Du, Xinyue"

作者地址："[Liu, Yuexi; Gu, Qiuying; Xiao, Yao] Chongqing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 1, Chongqing, Peoples R China; [Ni, Meng] Shanghai Jiao Tong Univ, Int Peace Matern & Child Hlth Hosp, Sch Med, Shanghai, Peoples R China; [Ni, Meng] Shanghai Key Lab Embryo Original Dis, Shanghai, Peoples R China; [Huang, Fanfan] Chongqing Med Univ, Dept Ophthalmol, Affiliated Hosp 1, Chongqing, Peoples R China; [Du, Xinyue] Chongqing Med Univ, Dept Cardiovasc Med, Affiliated Hosp 1, Chongqing, Peoples R China; [Liu, Yuexi] Chongqing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 1, Chongqing 400016, Peoples R China"

通信作者："Liu, YX (通讯作者)，Chongqing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 1, Chongqing 400016, Peoples R China."

来源：MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000923644200004

JCR分区：Q2

影响因子：1.3

年份：2023

卷号：102

期号：4

开始页：　

结束页：　

文献类型：Article

关键词：advanced ovarian cancer; cause-specific survival; neoadjuvant chemotherapy; overall survival; SEER

摘要："To evaluate the prognostic effect of neoadjuvant chemotherapy (NACT) in advanced epithelial ovarian cancer (EOC) patients with different histological subtype. Stage III/IV EOC patients diagnosed between 2010 and 2018 were identified from the surveillance, epidemiology, and end results database (SEER) database and stratified by histological subtype. Kaplan-Meier analysis was used for the assessment of overall survival (OS) cause-specific survival (CSS) before and after matching for baseline characteristics between NACT and primary debulking surgery (PDS) groups. Cox proportional risk model was conducted to identify independent prognostic factors. A total of 13,582 patients were included in the analysis. Of them, 9505 (74.50%) received PDS and 3253 (25.50%) received NACT. Overall, an inferior OS and CSS was observed among patients with high-grade serous carcinoma (HGSC) receiving NACT, while NACT served as a protective factor in clear cell carcinoma and carcinosarcoma in both original cohorts and adjusted cohorts. For other histo-subtypes, PDS showed survival benefit over NACT in certain cohorts of models. Prognostic effect of NACT in advanced EOC differed from pathological subtypes. Although it served as a risk factor for HGSC, patients with less common subtypes may benefit from NACT."

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