Association of the Monocyte-to-High-Density Lipoprotein Cholesterol Ratio with Gastrointestinal Involvement of Immunoglobulin a Vasculitis

作者全名："Shao, Xinyi; Li, Hao; Chen, Tingqiao; Chen, Yangmei; Qin, Xue; Liu, Lin; Luo, Xiaoyan; Chen, Jin"

作者地址："[Shao, Xinyi; Chen, Tingqiao; Chen, Yangmei; Qin, Xue; Liu, Lin; Chen, Jin] Chongqing Med Univ, Affiliated Hosp 1, Dept Dermatol, Chongqing 400010, Peoples R China; [Li, Hao; Luo, Xiaoyan] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ,Dept Dermatol,Key Lab Child Dev & Diso, Chongqing 400016, Peoples R China; [Luo, Xiaoyan] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ,Dept Dermatol,Key Lab Child Dev & Diso, 136 Zhongshan Second Rd, Chongqing 400016, Peoples R China; [Chen, Jin] Chongqing Med Univ, Affiliated Hosp 1, Dept Dermatol, 1 Youyi Rd, Chongqing 400010, Peoples R China"

通信作者："Luo, XY (通讯作者)，Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ,Dept Dermatol,Key Lab Child Dev & Diso, 136 Zhongshan Second Rd, Chongqing 400016, Peoples R China.; Chen, J (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Dermatol, 1 Youyi Rd, Chongqing 400010, Peoples R China."

来源：CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY

ESI学科分类：　

WOS号：WOS:000927441000001

JCR分区：Q3

影响因子：1.9

年份：2023

卷号：16

期号：　

开始页：359

结束页：367

文献类型：Article

关键词：monocyte-to-high-density lipoprotein cholesterol ratio; immunoglobulin A vasculitis; endothelial dysfunction; gastrointestinal involvement; inflammation

摘要："Objective: To illustrate the association of monocyte to high-density lipoprotein cholesterol ratio (MHR) and other serum indicators with the pathogenesis and prognosis of immunoglobulin A vasculitis (IgAV) patients in different subgroups. Methods: A total of 158 adult patients and 113 healthy controls were enrolled, and the clinical presentation and laboratory indexes were comprehensively assessed. Results: IgAV patients show significantly elevated levels of inflammatory parameters and lipid profiles compared to healthy controls (P < 0.05). Higher levels of the MHR and other normal inflammatory indicators were found in patients with Gastrointestinal (GI) involvement compared to other subgroups. And in group with GI involvement, significantly higher white blood cell (WBC), neutrophil, complement 4 (C4), NLR (neutrophil-to-lymphocyte ratio) and PLR (platelet-to-lymphocyte ratio) levels and lower levels of apolipoprotein-a (Apo-a) were observed. Their correlation analysis demonstrated positive results between MHR level and white blood cell (WBC) count (r = 0.416, P = 0.034), D-Dimer (r = 0.464, P = 0.026) and monocyte (r = 0.947, P < 0.001). And the time until first remission of skin purpura was shown positively correlated with their age (r = 0.456, P = 0.043), C-reactive protein (CRP) level (r = 0.641, P = 0.018), D-Dimer level (r = 0.502, P = 0.040) while negatively correlated with albumin (Alb) level (r=-0.626, P = 0.003) and low-density lipoprotein (LDL) level (r=-0.478, P = 0.033). Conclusion: Our study suggests that those biomarkers represented for inflammatory responses, lipid profile and immunological functions have significant differences in the subgroups of adult IgAV patients. In addition, we also found that MHR level may serve as a potential biomarker for the pathogenesis and prognosis of IgAV patients with GI involvement."

基金机构：National Natural Science Foundation of China [n82073462]

基金资助正文：Funding study was supported by the National Natural Science Foundation of China (n82073462) .