Novel antidepressant-like properties of the fullerenol in an LPS-induced depressive mouse model

作者全名："Kong, Anqi; Liu, Tianyao; Deng, Shilong; Xu, Shiyao; Luo, Yi; Li, Jianghui; Du, Zhulin; Wang, Liuyongwei; Xu, Xingshun; Fan, Xiaotang"

作者地址："[Kong, Anqi; Xu, Shiyao; Xu, Xingshun] Soochow Univ, Dept Neurol, Affiliated Hosp 1, Suzhou 215006, Peoples R China; [Kong, Anqi; Liu, Tianyao; Deng, Shilong; Luo, Yi; Li, Jianghui; Du, Zhulin; Wang, Liuyongwei; Fan, Xiaotang] Third Mil Med Univ, Army Med Univ, Sch Psychol, Dept Mil Cognit Psychol, Chongqing, Peoples R China; [Kong, Anqi; Xu, Shiyao; Xu, Xingshun] Soochow Univ, Inst Neurosci, Suzhou 215123, Peoples R China; [Fan, Xiaotang] Third Mil Med Univ, Sch Psychol, Dept Mil Cognit Psychol, Army Med Univ, Chongqing 400038, Peoples R China"

通信作者："Xu, XS (通讯作者)，Soochow Univ, Dept Neurol, Affiliated Hosp 1, Suzhou 215006, Peoples R China.; Fan, XT (通讯作者)，Third Mil Med Univ, Sch Psychol, Dept Mil Cognit Psychol, Army Med Univ, Chongqing 400038, Peoples R China."

来源：INTERNATIONAL IMMUNOPHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000931882500001

JCR分区：Q1

影响因子：4.8

年份：2023

卷号：116

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：LPS; Depression; Fullerenol; Hippocampus; Neuroinflammation

摘要："Depression is a common mental disease and is highly prevalent in populations. Dysregulated neuroinflammation and concomitant-activated microglia are involved in the pathogenesis of depression. Experimental evidence has indicated that fullerenol exerts anti-neuroinflammation and protective effects against neurological diseases. Here, we evaluated fullerenol's effects against lipopolysaccharide (LPS)-induced mouse depressive-like behav-iors. Fullerenol treatment produced an antidepressant-like effect, as indicated by preventing the LPS-induced reduction in the sucrose preference and shortening the immobility durations in both the tail suspension test and the forced swim test. We found that fullerenol treatment mitigated LPS-induced hippocampal microglia activation and released proinflammatory cytokines. Meanwhile, fullerenol promoted hippocampus neurogenesis, evidenced by increased DCX-positive cells in LPS-treated mice. Hippocampal RNA-Seq analysis revealed proin-flammatory cytokine and neurogenesis involved in fullerenol's antidepressant-like effects. Our data indicate that fullerenol exerts antidepressant effects, which might be due to beneficial functions in reducing neuro-inflammatory processes and promoting neurogenesis in the hippocampus."

基金机构：National Nature Science Foundation of China [82071544]; Innovation Research Group at Institutions of Higher Education in Chongqing [CXQT19010]

基金资助正文："This study was supported the National Nature Science Foundation of China (No. 82071544) , Innovation Research Group at Institutions of Higher Education in Chongqing (CXQT19010) , and the Priority Aca- demic Program Development of Jiangsu Higher Education Institutions of China."