Clinical study of the value of shear wave elastography in evaluating the degree of liver fibrosis in children

作者全名："Gao, Yang; Zhu, Lirong; Xiao, Huan; Yang, Chunjiang; Xu, Juan; Mou, Fangting; Tang, Yi"

作者地址："[Gao, Yang; Zhu, Lirong; Xiao, Huan; Yang, Chunjiang; Xu, Juan; Mou, Fangting; Tang, Yi] Chongqing Med Univ, Childrens Hosp, Dept Ultrasound, Chongqing, Peoples R China; [Gao, Yang; Zhu, Lirong; Xiao, Huan; Yang, Chunjiang; Xu, Juan; Mou, Fangting; Tang, Yi] Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ Key Lab Child Dev & Disorders, Chongqing 400014, Peoples R China; [Gao, Yang; Zhu, Lirong; Xiao, Huan; Yang, Chunjiang; Xu, Juan; Mou, Fangting; Tang, Yi] Chongqing Engn Res Ctr Stem Cell Therapy, Chongqing Key Lab Pediat, Chongqing 400014, Peoples R China"

通信作者："Xiao, H; Tang, Y (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Ultrasound, Chongqing, Peoples R China.; Xiao, H; Tang, Y (通讯作者)，Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ Key Lab Child Dev & Disorders, Chongqing 400014, Peoples R China.; Xiao, H; Tang, Y (通讯作者)，Chongqing Engn Res Ctr Stem Cell Therapy, Chongqing Key Lab Pediat, Chongqing 400014, Peoples R China."

来源：ABDOMINAL RADIOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000936277600001

JCR分区：Q2

影响因子：2.4

年份：2023

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期号：　

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文献类型：Article; Early Access

关键词：Liver elastography; Children; Shear wave elastography; Hepatomegaly

摘要："ObjectivesTo explore the clinical application of shear wave elastography (SWE) in evaluating the degree of liver fibrosis in children.MethodsTo explore the value of SWE in assessing liver fibrosis in children, the correlation between elastography values and the METAVIR grade of liver fibrosis in children with biliary system or liver diseases was studied. Children with significant liver enlargement were enrolled, and the fibrosis grade was analyzed to explore the value of SWE in assessing the degree of liver fibrosis in the presence of significant liver enlargement.ResultsA total of 160 children with bile system or liver diseases were recruited. The areas under the receiver operating characteristic curve (AUROCs) for liver biopsy from stage F1 to F4 were 0.990, 0.923, 0.819, and 0.884. According to the degree of liver fibrosis at liver biopsy, there was a high correlation between the SWE value and the degree of liver fibrosis (correlation coefficient 0.74). There was no significant correlation between the Young's modulus value of the liver and the degree of liver fibrosis (correlation coefficient 0.16).ConclusionsSupersonic SWE can generally accurately evaluate the degree of liver fibrosis in children with liver disease. However, When the liver is significantly enlarged, SWE can only evaluate liver stiffness based on Young's modulus values, and the degree of liver fibrosis must still be determined by pathologic biopsy."

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