Comparison of pregnancy outcomes between IVF-ET pregnancies and spontaneous pregnancies in women of advanced maternal age

作者全名："Lang, Manning; Zhou, Meiying; Lei, Ruobing; Li, Weihong"

作者地址："[Lang, Manning; Zhou, Meiying; Lei, Ruobing; Li, Weihong] Chongqing Med Univ, Affiliated Hosp 1, Reprod Med Ctr, Chongqing, Peoples R China"

通信作者："Li, WH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Reprod Med Ctr, Chongqing, Peoples R China."

来源：JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000940762000001

JCR分区：Q3

影响因子：1.7

年份：2023

卷号：36

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Advanced maternal age; assisted reproductive technology; pregnancy outcomes; IVF-ET; pregnancy complications

摘要："Aim To explore the impact of IVF on pregnancy complications and birth outcomes in women of advanced maternal age. Methods In this retrospective study, 3325 women were divided into the ART pregnancy group (n = 241) and the natural pregnancy group (n = 3086). The differences in maternal general conditions, pregnancy complications and birth outcomes were compared between the two groups. Results The ART group had higher rates of primiparity (78.4% vs 20.4%), cesarean section (90.5% vs 76.2%) and twin births (28.6% vs 2.1%). The risk of gestational hypertension (5.8% vs 2.9%), preeclampsia (5.0% vs 2.3%) and preterm birth [28 similar to 31 + 6 weeks (2.9% vs 1.1%), 32 similar to 33 + 6 weeks (5.0% vs 1.4%), 34 similar to 36 + 6 weeks (15.8% vs 9.4%)] was significantly higher in the ART group than in the natural pregnancy group. Neonates in the ART group had lower birth weights (2882.61 +/- 657.70 vs 3223.05 +/- 534.28). However, in the singleton-only comparison, only gestational hypertension still showed a statistically significant difference. Conclusions For women of advanced maternal age, IVF-ET pregnancies may result in higher rates of pregnancy complications and adverse birth outcomes, but this is likely to be due to increased rates of multiple pregnancies."

基金机构：National Natural Science Foundation of China [81501335]; General Program of Chongqing Natural Science Foundation [CSTB2022NSCQ-MSX0086]; Joint Program of the Chongqing Science and Technology Bureau; Chongqing Health Commission [2021MSXM141]

基金资助正文："This study was supported by grants from the National Natural Science Foundation of China (No. 81501335), the General Program of Chongqing Natural Science Foundation (CSTB2022NSCQ-MSX0086) and the Joint Program of the Chongqing Science and Technology Bureau and the Chongqing Health Commission (No. 2021MSXM141)."