A Study of the Association Between Carotid Artery Curvature and Intracranial Aneurysms

作者全名："Zhao, Jun; Xiang, Xiang; Zhang, Hongxia; Ye, Ying; He, Zhaohui"

作者地址："[Zhao, Jun] Dazhou Integrated TCM&Western Med Hosp, Dept Neurosurg, Dazhou, Peoples R China; [Ye, Ying] Sichuan Univ Arts & Sci, Sch Hlth caring Ind, Dazhou, Peoples R China; [Zhao, Jun; Xiang, Xiang; Zhang, Hongxia; He, Zhaohui] Chongqing Med Univ, Dept Neurosurg, Affiliated Hosp 1, Chongqing, Peoples R China; [He, Zhaohui] Chongqing Med Univ, Chongqing Univ Med Sci Clin Coll, Affiliated Hosp 1, Chongqing 400000, Peoples R China"

通信作者："He, ZH (通讯作者)，Chongqing Med Univ, Chongqing Univ Med Sci Clin Coll, Affiliated Hosp 1, Chongqing 400000, Peoples R China."

来源：NEUROLOGIST

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000945235800007

JCR分区：Q4

影响因子：1.1

年份：2023

卷号：28

期号：2

开始页：99

结束页：103

文献类型：Article

关键词：intracranial aneurysm; carotid artery curvature; weak vascular wall; pathogenesis; kinking; computed tomography angiography

摘要："Background:Carotid artery curvature is considered a sign of a weak vessel wall, and we hypothesize that a weak vascular wall under the effect of hemodynamics may cause intracranial aneurysms. Materials and Methods:The general data of 534 patients with aneurysms and 473 control patients were retrospectively analyzed in a case-control study. Carotid artery curvature was characterized as none, tortuosity, kinking, and coiling by computed tomography angiography images. Univariate analysis was performed to determine the degree of carotid artery tortuosity and to analyze the general data between the aneurysm group and the control group, and then, multivariate statistical logistic regression analysis was used to analyze the statistical significance of the univariate analysis. Finally, the correlation between aneurysm-related features and carotid artery curvature was analyzed. Results:Univariate analysis showed that kinking was significantly related to the occurrence of intracranial aneurysms (P=0.009). The results of multivariate regression analysis showed that kinking was an independent risk factor for the occurrence of aneurysms (odds ratio: 1.942; 95% confidence interval: 1.387-2.720 for model 1; odds ratio: 1.995; 95% confidence interval: 1.419-2.805 for model 2). In the analysis of the correlation between the characteristics of intracranial aneurysms and the curvature of the internal carotid artery, there was no correlation between the curvature of the internal carotid artery and the size, location or number of aneurysms, or whether the intracranial aneurysm was ruptured. Conclusion:Intracranial aneurysms are associated with carotid artery curvature. Kinking of the internal carotid artery may indicate a higher risk for aneurysm formation."

基金机构：National Natural Science Foundation of China [81870927]

基金资助正文：This study was funded by a grant from the National Natural Science Foundation of China (No. 81870927 to Z.H.)