Association of feeding patterns in infancy with later autism symptoms and neurodevelopment: a national multicentre survey

作者全名："Xiang, Xueli; Yang, Ting; Chen, Jie; Chen, Li; Dai, Ying; Zhang, Jie; Li, Ling; Jia, Feiyong; Wu, Lijie; Hao, Yan; Ke, Xiaoyan; Yi, Mingji; Hong, Qi; Chen, Jinjin; Fang, Shuanfeng; Wang, Yichao; Wang, Qi; Jin, Chunhua; Li, Tingyu"

作者地址："[Xiang, Xueli; Yang, Ting; Chen, Jie; Chen, Li; Dai, Ying; Li, Tingyu] Chongqing Med Univ, Childrens Nutr Res Ctr, Natl Clin Res Ctr Child Hlth & Disorders, Childrens Hosp,Chongqing Key Lab Childhood Nutr &, Chongqing, Peoples R China; [Zhang, Jie] Xian Childrens Hosp, Xian, Peoples R China; [Li, Ling] Hainan Women & Childrens Med Ctr, Dept Children Rehabil, Haikou, Peoples R China; [Jia, Feiyong] First Hosp Jilin Univ, Dept Dev & Behav Pediat, Changchun, Peoples R China; [Wu, Lijie] Harbin Med Univ, Dept Childrens & Adolescent Hlth, Publ Hlth Coll, Harbin, Peoples R China; [Hao, Yan] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pediat, Wuhan, Peoples R China; [Ke, Xiaoyan] Nanjing Brain Hosp, Child Mental Hlth Res Ctr, Nanjing, Peoples R China; [Yi, Mingji] Qingdao Univ, Dept Child Hlth Care, Affiliated Hosp, Qingdao, Peoples R China; [Hong, Qi] Maternal & Child Hlth Hosp Baoan, Shenzhen, Peoples R China; [Chen, Jinjin] Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Dept Child Healthcare, Shanghai, Peoples R China; [Fang, Shuanfeng] Zhengzhou Univ, Childrens Hosp, Zhengzhou, Peoples R China; [Wang, Yichao] Hunan Prov Maternal & Child Hlth Care Hosp, NHC Key Lab Birth Defect Res & Prevent, Changsha, Peoples R China; [Wang, Qi] Deyang Matern & Child Healthcare Hosp, Deyang, Peoples R China; [Jin, Chunhua] Capital Inst Pediat, Dept Children Hlth Care, Beijing, Peoples R China"

通信作者："Li, TY (通讯作者)，Chongqing Med Univ, Childrens Nutr Res Ctr, Natl Clin Res Ctr Child Hlth & Disorders, Childrens Hosp,Chongqing Key Lab Childhood Nutr &, Chongqing, Peoples R China."

来源：BMC PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:000951239700003

JCR分区：Q2

影响因子：3.4

年份：2023

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Autism spectrum disorder; Feeding patterns; Symptoms; Neurodevelopment; Multicenter survey

摘要："BackgroundWe aimed to compare differences in infant feeding patterns (breastfeeding and complementary food supplementation) between children with the autism spectrum disorder (ASD) and typically developing (TD) children through a multicentre study. The relationship between these patterns and later core symptoms and neurodevelopment in children with ASD was also investigated.MethodsWe analysed breastfeeding and complementary feeding patterns in 1389 children with ASD and 1190 TD children. The Children Neuropsychological and Behavior Scale-Revision 2016 (CNBS-R2016) was used to assess neurodevelopmental levels. The Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS), Childhood Autism Rating Scale (CARS), and ASD Warning Behavior Subscale of the CNBS-R2016 were used to assess ASD symptoms.ResultsChildren with ASD had a shorter breastfeeding duration in infancy (8 (3-12) months vs. 10 (6-14) months, P < 0.001), later introduction of complementary foods (P < 0.001), and poorer acceptance of complementary foods (P < 0.001) than TD children. Total ABC and CARS scores were lower in the group of children with ASD who had been breastfed for 12 months or more than in the group who had been breastfed for less than 6 months. Children with ASD who were given complementary food after 6 months had lower general quotient (GQ), adaptive ability, fine motor and language scores than those who were given complementary food within 4-6 months. Children with ASD with poor acceptance of complementary foods had higher ABC and SRS scores and lower gross motor scores than those who had good acceptance.ConclusionsChildren with ASD have a shorter duration of breastfeeding, a later introduction of complementary foods, and poorer acceptance of complementary foods than TD children. These feeding patterns may be related to the symptoms and growth of children with ASD. The research suggests that continued breastfeeding for longer than 12 months may be beneficial in reducing ASD symptoms and that infants who have difficulty introducing complementary foods should be followed up for neurodevelopment."

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