Correlations Between Inflammatory Cell Infiltration and Relative Density and the Boundary Manifestation of Pulmonary Non-Neoplastic Ground Glass Nodules

作者全名："Liu, Xiang-Ling; Lv, Fa-Jin; Fu, Bin-Jie; Lin, Rui-Yu; Li, Wang-Jia; Chu, Zhi-Gang"

作者地址："[Liu, Xiang-Ling; Lv, Fa-Jin; Fu, Bin-Jie; Lin, Rui-Yu; Li, Wang-Jia; Chu, Zhi-Gang] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, Chongqing, Peoples R China; [Chu, Zhi-Gang] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, 1 Youyi Rd, Yuanjiagang, Chongqing 400016, Peoples R China"

通信作者："Chu, ZG (通讯作者)，Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, 1 Youyi Rd, Yuanjiagang, Chongqing 400016, Peoples R China."

来源：JOURNAL OF INFLAMMATION RESEARCH

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000953653700001

JCR分区：Q2

影响因子：4.2

年份：2023

卷号：16

期号：　

开始页：1147

结束页：1155

文献类型：Article

关键词：tomography; X-ray computed; solitary pulmonary nodule; pathology

摘要："Purpose: To investigate the influence factors for the various boundary manifestations of pulmonary non-neoplastic ground glass nodules (GGNs) on computed tomography (CT).Materials and Methods: From January 2015 to March 2022, a total of 280 patients with 318 non-neoplastic GGNs were enrolled. The correlations between degree of inflammatory cell infiltration and relative density (Delta CT) and the boundary manifestations of lesions were evaluated, respectively.Results: Nongranulomatous nodules (283, 89.0%) with fibrous tissue proliferation and/or inflammatory cells as the predominant pathological findings were the most common non-neoplastic GGNs, followed by granulomatous nodules (28, 8.8%). Among nongranulomatous GGNs, cases with more and less/no inflammatory cells were 15 (10.9%) and 122 (89.1%) in 137 well-defined ones with smooth margin, 16 (24.6%) and 49 (75.4%) in 65 well-defined ones with coarse margin, 43 (91.5%) and 4 (8.5%) in 47 ill-defined ones with higher Delta CT (>151HU), and 4 (11.8%) and 30 (88.2%) in 34 ill-defined ones with lower Delta CT (< 151HU). The proportion of cases with more inflammatory cells in well-defined nodules was similar to that in ill-defined ones with lower Delta CT (P = 0.587) but significantly lower than that in ill-defined ones with higher Delta CT (P < 0.001). Among the granulomatous nodules, ill-defined cases with higher Delta CT (16, 57.1%) were the most common, and they (7/8, 87.5%) frequently had changes during short-term follow-up.Conclusion: Nongranulomatous nodules are the most common non-neoplastic GGNs, their diverse boundary manifestations closely correlate with degree of inflammatory cell infiltration and density difference."

基金机构：Joint Project of Chongqing Science and Technology Commission; Chongqing Public Health Commission [2022MSXM050]; Senior Medical Talents Program of Chongqing for Young and Middle- aged from Chongqing Health Commission

基金资助正文：Funding This work was supported by the Joint Project of Chongqing Science and Technology Commission and Chongqing Public Health Commission (2022MSXM050) and the Senior Medical Talents Program of Chongqing for Young and Middle- aged from Chongqing Health Commission (Receptor: Zhi-Gang Chu) .