Liquid chromatography-mass spectrometry-based metabolomic profiling reveals sex differences of lipid metabolism among the elderly from Southwest China

作者全名："Huang, Yuan-Jun; Ke, Wei; Hu, Ling; Wei, You-Dong; Dong, Mei-Xue"

作者地址："[Huang, Yuan-Jun] Chongqing Med Univ, Affiliated Hosp 1, Branch 1, Chongqing 430060, Peoples R China; [Ke, Wei; Hu, Ling; Dong, Mei-Xue] Wuhan Univ, Renmin Hosp, Hubei Gen Hosp, Dept Neurol, 238 Jiefang Rd, Wuhan, Hubei, Peoples R China; [Wei, You-Dong] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, 1 Youyi Rd, Yuzhong Dist, Chongqing 400016, Peoples R China"

通信作者："Dong, MX (通讯作者)，Wuhan Univ, Renmin Hosp, Hubei Gen Hosp, Dept Neurol, 238 Jiefang Rd, Wuhan, Hubei, Peoples R China.; Wei, YD (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, 1 Youyi Rd, Yuzhong Dist, Chongqing 400016, Peoples R China."

来源：BMC GERIATRICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000954580800001

JCR分区：Q2

影响因子：3.4

年份：2023

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Metabolomic analysis; Sex difference; The elderly; Lipid metabolism; Metabolite sets enrichment analysis

摘要："BackgroundThe sexual dimorphism represents one of the triggers of the metabolic disparities while the identification of sex-specific metabolites in the elderly has not been achieved.MethodsA group of aged healthy population from Southwest China were recruited and clinical characteristics were collected. Fasting plasma samples were obtained and untargeted liquid chromatography-mass spectrometry-based metabolomic analyses were performed. Differentially expressed metabolites between males and females were identified from the metabolomic analysis and metabolite sets enrichment analysis was employed.ResultsSixteen males and fifteen females were finally enrolled. According to clinical characteristics, no significant differences can be found except for smoking history. There were thirty-six differentially expressed metabolites between different sexes, most of which were lipids and lipid-like molecules. Twenty-three metabolites of males were increased while thirteen were decreased compared with females. The top four classes of metabolites were fatty acids and conjugates (30.6%), glycerophosphocholines (22.2%), sphingomyelins (11.1%), and flavonoids (8.3%). Fatty acids and conjugates, glycerophosphocholines, and sphingomyelins were significantly enriched in metabolite sets enrichment analysis.ConclusionsSignificant lipid metabolic differences were found between males and females among the elderly. Fatty acids and conjugates, glycerophosphocholines, and sphingomyelins may partly account for sex differences and can be potential treatment targets for sex-specific diseases."

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