Characteristics of cardiopulmonary exercise test in tracheobronchial tuberculosis patients with central airway stenosis

作者全名："Shui, Lili; Wang, Huyu; Yang, Binbin; Li, Guotao; Chen, Yajuan"

作者地址："[Shui, Lili; Yang, Binbin; Li, Guotao; Chen, Yajuan] Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing 400016, Peoples R China; [Wang, Huyu] Dept Chongqing Med Univ, Chongqing 400016, Peoples R China"

通信作者："Chen, YJ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing 400016, Peoples R China."

来源：HEART & LUNG

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000956798400001

JCR分区：Q1

影响因子：2.4

年份：2023

卷号：59

期号：　

开始页：73

结束页：81

文献类型：Article

关键词：Tracheobronchial tuberculosis; Central airway stenosis; Pulmonary function test; Cardiopulmonary exercise test

摘要："Background: A typical symptom of central airway stenosis is progressive dyspnea. The exercise capacity and relationship between pulmonary function testing (PFT) and central airway stenosis have not been reported. Objectives: To investigate, for the first time, the impact of central airway stenosis due to tracheobronchial tuberculosis (TBTB) on exercise capacity in adults. Methods: Fifty-one patients diagnosed with TBTB and 51 healthy, non-smoking adults (controls) were studied. All participants underwent a maximal cardiopulmonary exercise test (CPET) after completing PFT. Results: All participants completed the PFT and CPET. Significant differences existed between the two groups with respect to PFT parameters. At rest, no significant differences were detected between the two groups with respect to oxygen uptake (VO2), vital volume (VT), minute ventilation (VE), end-tidal carbon dioxide (PetCO(2)), and oxygen pulse (SPO2). Compared to controls, TBTB patients had lower peak work rate [WR, 100 (83,119) vs. 112 (95,146)], VO2 at maximal exercise (1309.51 +/- 323.83 vs. 1522.17 +/- 451.15), anaerobic threshold (905.8 +/- 219.84 vs. 1024.72 +/- 296.27), maximal O-2 pulse (8.02 +/- 1.61 vs. 9.26 +/- 2.36), and breath reserve [BR, 25 (15,42) vs. 49.5(39.4,61.3)]. The change in PetCO(2) values at rest and maximal exercise was lower than in controls (P<0.05). However, no difference in VE/carbon dioxide production (VCO2)@AT were demonstrated between the two groups. The correlations between the degree of stenosis, PFT parameters, and VO2 peak were significant. RV/TLC%pred was a good predictor of exercise limitation in these patients. Conclusion: The maximal exercise capacity and PFT parameters of TBTB patients with central airway stenosis were impaired. Impaired exercise capacity correlated with the degree of central airway stenosis. (c) 2023 Elsevier Inc. All rights reserved."

基金机构：Chongqing Health and Family Planning Commission?s Support Funds [2020MSXM274]

基金资助正文：Funding Chongqing Health and Family Planning Commission?s Support Funds (2020MSXM274) .