Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES

作者全名："Ling, Run; Ai, Yuanli; Chen, Chengzhi; Zhang, Jun; Zou, Zhen; Cheng, Shuqun; Li, Chunli; Li, Xi; Wang, Bin"

作者地址："[Ling, Run; Ai, Yuanli; Zhang, Jun; Zou, Zhen; Li, Chunli; Li, Xi; Wang, Bin] Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China; [Ling, Run; Chen, Chengzhi; Cheng, Shuqun] Chongqing Med Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Chongqing 400016, Peoples R China"

通信作者："Wang, B (通讯作者)，Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China."

来源：METABOLITES

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000958536900001

JCR分区：Q2

影响因子：3.4

年份：2023

卷号：13

期号：3

开始页：　

结束页：　

文献类型：Article

关键词：environmental chemical factors; bone mineral density; osteopenia; bone fracture; American adults; National Health and Nutrition Survey

摘要："To assess the association of environmental chemical factors with osteopenia and/or bone fractures. All data were extracted from the National Health and Nutrition Survey (NHANES) 2017-2018 of American adults aged 20-59 years old; invalid data were excluded based on dual-energy X-ray absorptiometry. For the ultimate valid data set, multivariate logistic regression models were applied to evaluate the association of environmental chemical factors with osteopenia and bone fractures. The valid dataset was obtained from 2640 individuals, who completed a questionnaire of demographic characteristics. Urinary manganese and monomethylarsonic acid were positively associated with osteopenia in American adults, but not bone fracture. However, several environmental factors (e.g., arsenous acid, arsenocholine, dimethylarsinic acid, and 2-thioxothiazolidine-4-carboxylic acid) did not affect bone mineral density, but were significantly associated with bone fracture. Multiple environmental chemical factors significantly affect bone mass or fracture risk. However, the risk of environmental chemical factors on fractures is independent of osteopenia in US Adults. The influence of environmental chemical factors on bone quality should be considered and monitored."

基金机构："Natural Science Foundation of Chongqing, China [CSTB2022NSCQ-MSX0110]; Science and Technology Research Program of Chongqing Municipal Education Commission [KJQN202000421]; Program for Youth Innovation in Future Medicine, Chongqing Medical University [W0046]"

基金资助正文："This research was funded by the Natural Science Foundation of Chongqing, China (CSTB2022NSCQ-MSX0110), the Science and Technology Research Program of Chongqing Municipal Education Commission (KJQN202000421), and the Program for Youth Innovation in Future Medicine, Chongqing Medical University (W0046)."