The comprehensive role of apoptosis inhibitor of macrophage (AIM) in pathological conditions

作者全名："Yang, Huiqing; Luo, Yan; Lai, Xiaofei"

作者地址："[Yang, Huiqing; Luo, Yan; Lai, Xiaofei] Chongqing Med Univ, Affiliated Hosp 1, Dept Lab Med, Chongqing 400016, Peoples R China; [Luo, Yan; Lai, Xiaofei] Chongqing Med Univ, Affiliated Hosp 1, Dept Lab Med, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China"

通信作者："Luo, Y; Lai, XF (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Lab Med, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China."

来源：CLINICAL AND EXPERIMENTAL IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000958941300001

JCR分区：Q3

影响因子：3.4

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：AIM; immunoregulation; inflammation; disease

摘要："CD5L/AIM (apoptosis inhibitor of macrophage), as an important component in maintaining tissue homeostasis and inflammation, is mainly produced and secreted by macrophages but partially dissociated and released from blood AIM-IgM. AIM plays a regulatory role in intracellular physiological mechanisms, including lipid metabolism and apoptosis. AIM not only increases in autoimmune diseases, directly targets liver cells in liver cancer and promotes cell clearance in acute kidney injury, but also causes arteriosclerosis and cardiovascular events, and aggravates inflammatory reactions in lung diseases and sepsis. Obviously, AIM plays a pleiotropic role in the body. However, to date, studies have failed to decipher the mechanisms behind its different roles (beneficial or harmful) in inflammatory regulation. The inflammatory response is a ""double-edged sword,"" and maintaining balance is critical for effective host defense while minimizing the adverse side effects of acute inflammation. Enhancing the understanding of AIM function could provide the theoretical basis for new therapies in these pathological settings. In this review, we discuss recent studies on the roles of AIM in lipid metabolism, autoimmune diseases and organic tissues, such as liver cancer, myocardial infarction, and kidney disease. AIM plays a regulatory role in intracellular physiological mechanisms, including lipid metabolism and apoptosis. AIM not only increases its expression in autoimmune diseases, directly targets liver cells in liver cancer and promotes cell clearance in acute kidney injury, but also causes arteriosclerosis and cardiovascular events, and aggravates inflammatory reactions in lung diseases and sepsis. Obviously, AIM plays a pleiotropic role in the body."

基金机构：National Natural Science Foundation of China [81901582]; Natural Science Foundation of Chongqing [cstc2021jcyj-msxmX0123]

基金资助正文：This review is supported by National Natural Science Foundation of China (No. 81901582) and Natural Science Foundation of Chongqing (No. cstc2021jcyj-msxmX0123).