Risk factors for persistent fever in children with infectious mononucleosis

作者全名："Zhou, Jiwei; Cao, Jie; Deng, Boyin"

作者地址："[Zhou, Jiwei; Cao, Jie; Deng, Boyin] Chongqing Med Univ, Dept Gen Med, Childrens Hosp, Chongqing, Peoples R China; [Deng, Boyin] Chongqing Med Univ, Dept Med Gen Ward, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ,Key Lab Child Dev & Disorders,Children, Chongqing 400014, Peoples R China"

通信作者："Deng, BY (通讯作者)，Chongqing Med Univ, Dept Med Gen Ward, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ,Key Lab Child Dev & Disorders,Children, Chongqing 400014, Peoples R China."

来源：PEDIATRICS INTERNATIONAL

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000960916600001

JCR分区：Q3

影响因子：1

年份：2023

卷号：65

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：blood triglyceride; children; fever; infectious mononucleosis; risk factor

摘要："Background: Fever is a common symptom in children with infectious mononucleosis (IM). However, the significance of the duration of a fever is poorly understood. This study aimed to analyze the risk factors for persistent fever in children with IM.Methods: Patients diagnosed with IM (aged <18 years; except those with concomitant hematological malignancies or tumor diseases) in a high-volume academic hospital in 2019 were reviewed from a prospectively maintained database. Children with transient fever (=7 days) were compared with those with persistent fever (>7 days). The risk factors for persistent fever in children with IM were examined using binary logistic regression. Furthermore, the predictive ability of these risk factors was assessed and presented using a receiver operating characteristic (ROC) curve.Results: Of the 184 children included in this study, 131 (71.96%) belonged to the transient fever group and 53 (28.04%) belonged to the persistent fever group (median age: 49 and 64 months, respectively; p = 0.093). Statistical significance was observed in hepatomegaly, alanine aminotransferase level, blood triglyceride level, and blood Epstein-Barr virus polymerase chain reaction (EBV-PCR) copy number (all p < 0.05). Binary logistic regression revealed that high blood triglyceride level was the risk factor for persistent fever in children with IM. High blood triglyceride level predicted persistent fever duration with an area under the ROC curve of 0.73 and an optimal cutoff value of 1.315 mmol/L.Conclusion: High blood triglyceride level was the risk factor for persistent fever in children with IM. Thus, children with elevated levels of blood triglycerides need additional care. To diagnose IM, a blood EBV-PCR is more useful than a throat-swab EBV-PCR."

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