Dual-Oxygenation/Dual-Fenton Synergistic Photothermal/ Chemodynamic/Starvation Therapy for Tumor Treatment

作者全名："Kang, Hongmei; Chen, Lamei; Li, Qin; Chen, Huan; Zhang, Liangke"

作者地址："[Kang, Hongmei; Chen, Lamei; Li, Qin; Chen, Huan; Zhang, Liangke] Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China"

通信作者："Zhang, LK (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing, Peoples R China."

来源：ACS APPLIED MATERIALS & INTERFACES

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000961193600001

JCR分区：Q1

影响因子：8.3

年份：2023

卷号：15

期号：12

开始页：15129

结束页：15139

文献类型：Article

关键词：photothermal therapy; chemodynamic therapy; starvation therapy; dual-Fenton; synergistic treatment

摘要："Due to the complexity of tumor pathogenesis and the heterogeneity of the tumor microenvironment (TME), it is difficult to obtain satisfactory efficacy with a single therapy. In this study, a hyaluronic acid (HA)-modified ruthenium nanoaggregate (RuNA) and glucose oxidase (GOD)-loaded manganese dioxide (MnO2) nanoflowers (MRG@HA) have been prepared. RuNA and MnO2 nanoflowers can generate O2 in TME, alleviating tumor tissue hypoxia. RuNA is a good photothermal agent for high-temperature ablation of solid tumors under infrared laser irradiation. GOD consumes glucose in the presence of O2 and converts it into glucuronic acid and hydrogen peroxide, reducing tumor nutrient supply while promoting Fenton-like reactions of MnO2 nanoflowers and RuNA to produce cytotoxic hydroxyl radicals. MRG@HA can also actively target tumor cells through the affinity of HA and CD44 receptor to improve the antitumor effect. In vitro and in vivo studies have confirmed the synergistic effect of MRG@HA with tumor photothermal/chemodynamic/starvation therapy, showing its great potential for clinical application in tumor therapy."

基金机构：Natural Science Foundation Project of CQ CSTC [cstc2018jcyjAX0795]; National Natural Science Foundation of China [81871368]

基金资助正文：? ACKNOWLEDGMENTS This work was supported by the Natural Science Foundation Project of CQ CSTC (cstc2018jcyjAX0795) and the National Natural Science Foundation of China (81871368) .