Frequency-resolved connectome alterations in major depressive disorder: A multisite resting fMRI study

作者全名："Wang, Lei; Ma, Qing; Sun, Xiaoyi; Xu, Zhilei; Zhang, Jiaying; Liao, Xuhong; Wang, Xiaoqin; Wei, Dongtao; Chen, Yuan; Liu, Bangshan; Huang, Chu-Chung; Zheng, Yanting; Wu, Yankun; Chen, Taolin; Cheng, Yuqi; Xu, Xiufeng; Gong, Qiyong; Si, Tianmei; Qiu, Shijun; Lin, Ching-Po; Cheng, Jingliang; Tang, Yanqing; Wang, Fei; Qiu, Jiang; Xie, Peng; Li, Lingjiang; He, Yong; DIDA MDD Working Grp, Mingrui; Xia, Mingrui; Zhang, Yihe"

作者地址："[Wang, Lei; Sun, Xiaoyi; Xu, Zhilei; Zhang, Jiaying; He, Yong; Xia, Mingrui; Zhang, Yihe] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China; [Wang, Lei; Sun, Xiaoyi; Xu, Zhilei; Zhang, Jiaying; He, Yong; Xia, Mingrui; Zhang, Yihe] Beijing Normal Univ, Beijing Key Lab Brain Imaging & Connect, Beijing, Peoples R China; [Wang, Lei; Sun, Xiaoyi; Xu, Zhilei; Zhang, Jiaying; He, Yong; Xia, Mingrui; Zhang, Yihe] Beijing Normal Univ, McGovern Inst Brain Res, IDG, Beijing, Peoples R China; [Ma, Qing] Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai, Peoples R China; [Ma, Qing] Fudan Univ, State Key Lab Med Neurobiol, Shanghai, Peoples R China; [Ma, Qing] Fudan Univ, MOE Frontiers Ctr Brain Sci, Shanghai, Peoples R China; [Sun, Xiaoyi; Liao, Xuhong] Beijing Normal Univ, Sch Syst Sci, Beijing, Peoples R China; [Wang, Xiaoqin; Wei, Dongtao; Qiu, Jiang] Minist Educ, Key Lab Cognit & Personal SWU, Chongqing, Peoples R China; [Wang, Xiaoqin; Wei, Dongtao; Qiu, Jiang] Southwest Univ, Dept Psychol, Chongqing, Peoples R China; [Chen, Yuan; Cheng, Jingliang] Zhengzhou Univ, Affiliated Hosp 1, Dept Magnet Resonance Imaging, Zhengzhou, Peoples R China; [Liu, Bangshan; Li, Lingjiang] Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Dept Psychiat, Changsha, Hunan, Peoples R China; [Liu, Bangshan; Li, Lingjiang] Cent South Univ, Mental Hlth Inst, China Natl Technol Inst Mental Disorders, Hunan Med Ctr Mental Hlth,Hunan Key Lab Psychiat &, Changsha, Hunan, Peoples R China; [Huang, Chu-Chung] East China Normal Univ, Sch Psychol & Cognit Sci, Inst Cognit Neurosci, Minist Educ,Shanghai Key Lab Brain Funct Genom, Shanghai, Peoples R China; [Zheng, Yanting; Qiu, Shijun] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Radiol, Guangzhou, Peoples R China; [Wu, Yankun; Si, Tianmei] Peking Univ, Peking Univ Sixth Hosp, Inst Mental Hlth, Natl Clin Res Ctr Mental Disorders,NHC Key Lab Men, Beijing, Peoples R China; [Chen, Taolin; Gong, Qiyong] Sichuan Univ, West China Hosp, Huaxi MR Res Ctr HMRRC, Dept Radiol, Chengdu, Peoples R China; [Cheng, Yuqi] Kunming Med Univ, Affiliated Hosp 1, Dept Psychiat, Kunming, Peoples R China; [Xu, Xiufeng; Gong, Qiyong] Chinese Acad Med Sci, Res Unit Psychoradiol, Chengdu, Sichuan, Peoples R China; [Lin, Ching-Po] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, Crespigny Pk, London, England; [Lin, Ching-Po] Natl Yang Ming Chiao Tung Univ, Inst Neurosci, Taipei, Taiwan; [Tang, Yanqing; Wang, Fei] China Med Univ, Affiliated Hosp 1, Dept Psychiat, Shenyang, Peoples R China; [Xie, Peng] Chongqing Key Lab Neurobiol, Chongqing, Peoples R China; [Xie, Peng] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China; [He, Yong] Chinese Inst Brain Res, Beijing, Peoples R China; [Xia, Mingrui; Zhang, Yihe] Beijing Normal Univ, McGovern Inst Brain Res, State Key Lab Cognit Neurosci & Learning, Beijing Key Lab Brain Imaging & Connect, Beijing 100875, Peoples R China"

通信作者："Xia, MR; Zhang, YH (通讯作者)，Beijing Normal Univ, McGovern Inst Brain Res, State Key Lab Cognit Neurosci & Learning, Beijing Key Lab Brain Imaging & Connect, Beijing 100875, Peoples R China."

来源：JOURNAL OF AFFECTIVE DISORDERS

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:000962813300001

JCR分区：Q1

影响因子：4.9

年份：2023

卷号：328

期号：　

开始页：47

结束页：57

文献类型：Article

关键词：Resting -state functional magnetic resonance; imaging; Major depressive disorder; Functional connectivity strength; Frequency

摘要："Background: Functional connectome studies have revealed widespread connectivity alterations in major depressive disorder (MDD). However, the low frequency bandpass filtering (0.01-0.08 Hz or 0.01-0.1 Hz) in most studies have impeded our understanding on whether and how these alterations are affected by frequency of interest.Methods: Here, we performed frequency-resolved (0.01-0.06 Hz, 0.06-0.16 Hz and 0.16-0.24 Hz) connectome analyses using a large-sample resting-state functional MRI dataset of 1002 MDD patients and 924 healthy controls from seven independent centers.Results: We reported significant frequency-dependent connectome alterations in MDD in left inferior parietal, inferior temporal, precentral, and fusiform cortices and bilateral precuneus. These frequency-dependent con-nectome alterations are mainly derived by abnormalities of medium-and long-distance connections and are brain network-dependent. Moreover, the connectome alteration of left precuneus in high frequency band (0.16-0.24 Hz) is significantly associated with illness duration.Limitations: Multisite harmonization model only removed linear site effects. Neurobiological underpinning of alterations in higher frequency (0.16-0.24 Hz) should be further examined by combining fMRI data with respiration, heartbeat and blood flow recordings in future studies.Conclusions: These results highlight the frequency-dependency of connectome alterations in MDD and the benefit of examining connectome alteration in MDD under a wider frequency band."

基金机构："National Natural Science Foundation of China [82071998, 82021004, 81620108016, 91432115, 81171286, 91232714, 31771231, 31271087, 81571331, 81271499, 81571311, 81920108019, 81771344, 81630031, 81621003, 81660237]; Beijing Nova Program [Z191100001119023]; Beijing United Imaging Research Institute of Intelligent Imaging Foundation [CRIBJZD202102]; Fundamental Research Funds for the Central Universities [2020NTST29]; National Key Research and Development Program of China [2018YFA0701400]; Changjiang Scholar Professorship Award [T2015027]; National Basic Research Program of China [2015AA020513]; Natural Science Foundation of Chongqing; National High-Tech Research and Development Program (863) [17JC1404105]; Medical Science and Technology Research Project of Henan Province [17JC1404101]; National Science and Technologic Program of China; Shanghai Science and Technology Innovation Plan [cstc2019jcyj-msxmX0520, 2015BAI13B02]; [2013CB835100]; [201701011]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (82071998 to M.X.; 82021004, 81620108016, and 91432115 to Y.H.; 81171286 and 91232714 to L.L.; 31771231 and 31271087 to J. Q.; 81571331 to F.W.; 81271499 and 81571311 to Y.T.; 81920108019 and 81771344 to S.Q.; 81630031 to T.S.; 81621003 to Q.G.; and 81660237 to X.X.) , the Beijing Nova Program (Z191100001119023 to M.X.) , the Beijing United Imaging Research Institute of Intelligent Imaging Foundation (CRIBJZD202102 to M.X.) , the Fundamental Research Funds for the Central Universities (2020NTST29 to M.X.) , the National Key Research and Development Program of China (2018YFA0701400 to Y.H.) , the Changjiang Scholar Professorship Award (T2015027 to Y.H.) , the National Science and Technologic Program of China (2015BAI13B02 to L.L.) , the National Basic Research Program of China (2013CB835100 L.L.) , the Natural Science Foundation of Chongqing (cstc2019jcyj-msxmX0520 to J.Q.) , the National High -Tech Research and Develop- ment Program (863) (2015AA020513 to F.W.) , the Medical Science and Technology Research Project of Henan Province (201701011 to J. Cheng) , and the Shanghai Science and Technology Innovation Plan (17JC1404105 and 17JC1404101 to C.-P.L.) ."