Cord blood adiponectin and leptin concentrations in monochorionic twins with selective intrauterine growth restriction and their associations with childhood growth trajectories

作者全名："Wen, Li; Fu, Huijia; Saffery, Richard; Tong, Chao; Liu, Yamin; Kilby, Mark D.; Qi, Hongbo; Baker, Philip N."

作者地址："[Wen, Li; Tong, Chao; Qi, Hongbo] Chongqing Med Univ, Affiliated Hosp 1, State Key Lab Maternal & Fetal Med Chongqing Munic, Chongqing 400016, Peoples R China; [Wen, Li; Liu, Yamin; Qi, Hongbo] Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet, Chongqing 401147, Peoples R China; [Fu, Huijia] Chongqing Med Univ, Affiliated Hosp 1, Reprod Med Ctr, Chongqing 400016, Peoples R China; [Saffery, Richard] Royal Childrens Hosp, Murdoch Childrens Res Inst, Mol Immun, Melbourne, Vic, Australia; [Saffery, Richard] Univ Melbourne, Dept Pediat, Parkville, Vic, Australia; [Kilby, Mark D.] Birmingham Womens & Childrens Fdn Trust, Fetal Med Ctr, Birmingham B15 2TG, England; [Kilby, Mark D.] Univ Birmingham, Inst Metab & Syst Res, Coll Med & Dent Sci, Birmingham B15 2TT, England; [Baker, Philip N.] Univ Leicester, Coll Life Sci, Leicester LE1 7RH, England"

通信作者："Tong, C; Qi, HB (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, State Key Lab Maternal & Fetal Med Chongqing Munic, Chongqing 400016, Peoples R China.; Liu, YM; Qi, HB (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet, Chongqing 401147, Peoples R China."

来源：PEDIATRIC OBESITY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000963094300001

JCR分区：Q1

影响因子：2.7

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：adiponectin; childhood growth; leptin; monochorionic twins; selective intrauterine growth restriction

摘要："BackgroundBeing born with intrauterine growth restriction (IUGR) was associated with subsequent health issues later in life. However, the underlying role of adipokines in IUGR is unknown. ObjectivesTo measure the adiponectin and leptin concentrations in the cord blood of monochorionic (MC) twins with selective IUGR (sIUGR) and evaluate their associations with childhood growth trajectories. MethodsCord blood samples were collected from 22 pairs of MC twins with sIUGR and 20 pairs of normal MC twins. Adiponectin and leptin concentrations in cord blood were determined by ELISA. Data regarding perinatal outcomes and infantile growth trajectories from birth to 24 months were obtained. ResultsOnly cord blood adiponectin concentrations were associated with IUGR (beta -1.51, 95% CI -2.45, -0.57, p = 0.002), and cord blood leptin concentrations were significantly lower in sIUGR twins compared to normal twins (2.8 +/- 1.6 vs. 6.4 +/- 3.0, p < 0.001). Adiponectin concentrations were negatively associated with height increments from birth to 6 months (beta -0.28, 95% CI -0.51, -0.06, p = 0.015). Leptin concentrations were negatively associated with weight at 6 and 24 months (beta -0.12 95% CI -0.22, -0.02, p = 0.002; beta -0.18 95% CI -0.33, -0.03, p = 0.019) and weight and height increments from birth to 6 months (beta -0.17 95% CI -0.29, -0.06, p = 0.020; beta -0.40 95% CI -0.81, -0.01, p = 0.037). ConclusionCord blood adiponectin concentrations were negatively associated with IUGR but did not predict childhood growth. Cord blood leptin concentrations were inversely associated with weight and height increments in the first 6 months."

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