Physicians' knowledge of invasive fungal disease in China

作者全名："Chen, Yijian; Huang, Xiaojun; Qiu, Haibo; Cheng, Linling; Yu, Yunsong; Ma, Xiaochun; Feng, Sizhou; Li, Qi; Wu, Depei; Huang, Wenxiang; Chen, Dechang; Lv, Xiaoju; Hu, Jianda; Wang, Jingbo; Li, Jiabin; Yang, Wenjie; Zhan, Qingyuan; Sun, Bing; Wang, Minggui"

作者地址："[Chen, Yijian; Wang, Minggui] Fudan Univ, Huashan Hosp, Inst Antibiot, Shanghai, Peoples R China; [Chen, Yijian; Wang, Minggui] Natl Hlth Commiss, Key Lab Clin Pharmacol Antibiot, Shanghai, Peoples R China; [Huang, Xiaojun] Peking Univ, Peoples Hosp, Beijing Key Lab Hematopoiet Stem Cell Transplantat, Beijing, Peoples R China; [Qiu, Haibo] Southeast Univ, Zhongda Hosp, Sch Med, Dept Crit Care Med,Jiangsu Prov Key Lab Crit Care, Nanjing, Peoples R China; [Cheng, Linling] Guangzhou Med Univ, Affiliated Hosp 1, Dept Resp, Guangzhou, Peoples R China; [Yu, Yunsong] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Infect Dis, Hangzhou, Peoples R China; [Ma, Xiaochun] China Med Univ, Affiliated Hosp 1, Dept Crit Care Med, Shenyang, Peoples R China; [Feng, Sizhou] Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol & Blood Dis Hosp, Dept Hematol, Tianjin, Peoples R China; [Li, Qi] Mil Med Univ, Affiliated Hosp 2, Dept Resp, Chongqing, Peoples R China; [Wu, Depei] Soochow Univ, Affiliated Hosp 1, Dept Hematol, Suzhou, Peoples R China; [Huang, Wenxiang] Chongqing Med Univ, Affiliated Hosp 1, Dept Infect Dis, Chongqing, Peoples R China; [Chen, Dechang] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Crit Care Med, Shanghai, Peoples R China; [Hu, Jianda] Sichuan Univ, West China Hosp, Ctr Infect Dis, Chengdu, Peoples R China; [Hu, Jianda] Fujian Med Univ, Union Hosp, Dept Hematol, Fujian, Peoples R China; [Wang, Jingbo] Aerosp Cent Hosp, Dept Hematol, Beijing, Peoples R China; [Li, Jiabin] Anhui Med Univ, Affiliated Hosp 1, Dept Infect Dis, Hefei, Anhui, Peoples R China; [Yang, Wenjie] Tianjin First Ctr Hosp, Dept Infect Dis, Tianjin, Peoples R China; [Zhan, Qingyuan] Sino Japanese Friendship Hosp, Dept Resp, Intens Care Unit, Beijing, Peoples R China; [Sun, Bing] Capital Med Univ, Beijing Chaoyang Hosp, Intens Care Unit, Beijing, Peoples R China; [Wang, Minggui] Fudan Univ, Huashan Hosp, Inst Antibiot, 12 M Wulumuqi Rd, Shanghai 200040, Peoples R China"

通信作者："Wang, MG (通讯作者)，Fudan Univ, Huashan Hosp, Inst Antibiot, 12 M Wulumuqi Rd, Shanghai 200040, Peoples R China."

来源：MYCOSES

ESI学科分类：PLANT & ANIMAL SCIENCE

WOS号：WOS:000971184200001

JCR分区：Q1

影响因子：4.1

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：aspergillosis; candidiasis; cryptococcosis; invasive fungal infections; mucormycosis; surveys and questionnaires

摘要："Background: Invasive fungal disease (IFD) is associated with high morbidity and mortality. Data are lacking regarding physicians' perspectives on the diagnosis and management of IFD in China. Objectives: To evaluate physicians' perspectives on the diagnosis and management of IFD. Methods: Based on current guidelines, a questionnaire was designed and administered to 294 physicians working in haematology departments, intensive care units, respiratory departments and infectious diseases departments in 18 hospitals in China. Results: The total score and subsection scores for invasive candidiasis, invasive aspergillosis (IA), cryptococcosis and invasive mucormycosis (IM) were 72.0 +/- 12.2 (maximum = 100), 11.1 +/- 2.7 (maximum = 19), 43.0 +/- 7.8 (maximum = 57), 8.1 +/- 2.0 (maximum = 11) and 9.8 +/- 2.3 (maximum = 13), respectively. Although the perspectives of the Chinese physicians were in good overall agreement with guideline recommendations, some knowledge gaps were identified. Specific areas in which the physicians' perspectives and guideline recommendations differed included use of the beta-D-glucan test to facilitate the diagnosis of IFD, relative utility of the serum galactomannan test and bronchoalveolar lavage fluid galactomannan test in patients with agranulocytosis, use of imaging in the diagnosis of mucormycosis, risk factors for mucormycosis, indications for initiating antifungal therapy in patients with haematological malignancies, when to start empirical therapy in mechanically ventilated patients, first-line drugs for mucormycosis and treatment courses for IA and IM. Conclusion: This study highlights the main areas that could be targeted by training programs to improve the knowledge of physicians treating patients with IFD in China."

基金机构：National Capacity Building Program for Multidisciplinary Cooperation in Diagnosis and Treatment of Major Diseases (Multidrug Resistant Bacterial Infections); Pfizer fund QI

基金资助正文："This study was supported by National Capacity Building Program for Multidisciplinary Cooperation in Diagnosis and Treatment of Major Diseases (Multidrug Resistant Bacterial Infections) and the Pfizer fund QI. The funders did not participate in the study design, data collection and analysis, or manuscript preparation."