"Heparin-binding protein as a biomarker of severe sepsis in the pediatric intensive care unit: A multicenter, prospective study"

作者全名："Liu, Pengcheng; Chen, Dapeng; Lou, Jintu; Lin, Jiancheng; Huang, Caizhi; Zou, Yun; Wong, Cai; Wu, Haiming; Yang, Gangfeng; Liu, Jing; Zhou, Zhenwen; Gao, Fei; Gao, Ling; Long, Guangfeng; Ma, Lijuan; Dai, Shuzhi; Qu, Wei; Mo, Liya; Shang, Shiqiang; Xu, Jin"

作者地址："[Liu, Pengcheng; Xu, Jin] Fudan Univ, Childrens Hosp, Natl Childrens Med Ctr, Dept Clin Lab, Shanghai 201102, Peoples R China; [Chen, Dapeng; Wong, Cai] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Clin Lab, Chongqing 400016, Peoples R China; [Lou, Jintu; Shang, Shiqiang] Zhejiang Univ, Childrens Hosp, Sch Med, Dept Clin Lab, Hangzhou 310052, Peoples R China; [Lin, Jiancheng] Fudan Univ Xiamen, Childrens Hosp Xiamen, Childrens Hosp, Dept Clin Lab, Xiamen 361006, Peoples R China; [Huang, Caizhi; Mo, Liya] Hunan Childrens Hosp, Dept Clin Lab, Changsha 410007, Peoples R China; [Zou, Yun; Qu, Wei] Guiyang Childrens Hosp, Guiyang Maternal & Child Hlth Care Hosp, Dept Clin Lab, Guiyang 550003, Peoples R China; [Yang, Gangfeng; Liu, Jing] Fudan Univ, Childrens Hosp, Natl Childrens Med Ctr, Pediat Intens Care Unit, Shanghai 201102, Peoples R China; [Zhou, Zhenwen] Longgang Matern & Child Healthcare Hosp, Dept Clin Lab, Shenzhen 510623, Peoples R China; [Gao, Fei] Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Dept Clin Lab, Guangzhou 510623, Peoples R China; [Gao, Ling; Long, Guangfeng] Nanjing Med Univ, Childrens Hosp, Dept Clin Lab, Nanjing 210008, Peoples R China; [Ma, Lijuan; Dai, Shuzhi] Childrens Hosp, Capital Inst Pediat, Dept Clin Lab, Beijing 100020, Peoples R China; [Xu, Jin] Fudan Univ, Shanghai Inst Infect Dis & Biosecur, Shanghai, Peoples R China"

通信作者："Xu, J (通讯作者)，Fudan Univ, Childrens Hosp, Natl Childrens Med Ctr, Dept Clin Lab, Shanghai 201102, Peoples R China.; Shang, SQ (通讯作者)，Zhejiang Univ, Childrens Hosp, Sch Med, Dept Clin Lab, Hangzhou 310052, Peoples R China.; Mo, LY (通讯作者)，Hunan Childrens Hosp, Dept Clin Lab, Changsha 410007, Peoples R China.; Qu, W (通讯作者)，Guiyang Childrens Hosp, Guiyang Maternal & Child Hlth Care Hosp, Dept Clin Lab, Guiyang 550003, Peoples R China.; Xu, J (通讯作者)，Fudan Univ, Shanghai Inst Infect Dis & Biosecur, Shanghai, Peoples R China."

来源：CLINICA CHIMICA ACTA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000974648800001

JCR分区：Q2

影响因子：3.2

年份：2023

卷号：539

期号：　

开始页：26

结束页：33

文献类型：Article

关键词：Children; Diagnosis; Heparin -binding protein (HBP); Prognosis; Severe sepsis; Pediatric intensive care unit (PICU)

摘要："Objectives: The aim of this study is to assess Heparin-binding protein (HBP) as a diagnostic and prognostic biomarker of severe sepsis in the pediatric intensive care unit (PICU).Methods: A multicenter, prospective study was conducted among children with sepsis in nine PICUs in China from October 2019 to June 2021. Plasma levels of HBP, procalcitonin (PCT), C-reactive protein (CRP), lactate, and white blood cell (WBC) count were determined at enrollment and 72 h after enrollment.Results: Of 355 included patients, 132 patients were diagnosed with non-severe sepsis (referred to as sepsis), 223 patients had severe sepsis. Patients with severe sepsis had significantly elevated levels of HBP compared with sepsis (median 170.5 vs. 74.1 ng/mL, P < 0.001). Adding HBP to a diagnostic model with PCT and lactate could significantly improve the diagnostic capability for severe sepsis. The plasma levels of HBP correlated positively with the number of dysfunctional organs. After adjusting for confounding factors, the declined levels of HBP at 72 h had a significant association with decreased in-hospital mortality (adjusted odds ratio (aOR) 0.242, P < 0.001). The levels of HBP showed weak positive correlations with PCT, CRP, WBC, and no correlation to lactate.Conclusions: HBP at enrollment can be an independent indicator for severe sepsis and the dynamic changes at 72 h can be a predictor for in-hospital mortality in PICU."

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