Epidemiological and genetic evidence for the relationship between ABO blood group and human cancer

作者全名："Cui, Huijie; Qu, Yang; Zhang, Li; Zhang, Wenqiang; Yan, Peijing; Yang, Chao; Zhang, Min; Bai, Ye; Tang, Mingshuang; Wang, Yutong; Chen, Lin; Xiao, Chenghan; Zou, Yanqiu; Liu, Yunjie; Zhang, Ling; Yang, Yanfang; Yao, Yuqin; Li, Jiayuan; Liu, Zhenmi; Yang, Chunxia; Jiang, Xia; Zhang, Ben"

作者地址："[Cui, Huijie; Qu, Yang; Zhang, Li; Zhang, Wenqiang; Yan, Peijing; Yang, Chao; Tang, Mingshuang; Wang, Yutong; Chen, Lin; Zou, Yanqiu; Liu, Yunjie; Yang, Yanfang; Li, Jiayuan; Yang, Chunxia; Jiang, Xia; Zhang, Ben] Sichuan Univ, Inst Syst Epidemiol, Dept Epidemiol & Biostat, Chengdu, Sichuan, Peoples R China; [Cui, Huijie; Qu, Yang; Zhang, Li; Zhang, Wenqiang; Yan, Peijing; Yang, Chao; Tang, Mingshuang; Wang, Yutong; Chen, Lin; Zou, Yanqiu; Liu, Yunjie; Yang, Yanfang; Li, Jiayuan; Yang, Chunxia; Jiang, Xia; Zhang, Ben] Sichuan Univ, West China Sch Publ Hlth, West China PUMC C C Chen Inst Hlth, Chengdu, Sichuan, Peoples R China; [Cui, Huijie; Qu, Yang; Zhang, Li; Zhang, Wenqiang; Yan, Peijing; Yang, Chao; Tang, Mingshuang; Wang, Yutong; Chen, Lin; Xiao, Chenghan; Zou, Yanqiu; Liu, Yunjie; Yang, Yanfang; Yao, Yuqin; Li, Jiayuan; Liu, Zhenmi; Yang, Chunxia; Jiang, Xia; Zhang, Ben] Sichuan Univ, West China Hosp 4, Chengdu, Sichuan, Peoples R China; [Zhang, Min; Bai, Ye] Chongqing Med Univ, Sch Publ Hlth & Management, Dept Epidemiol & Hlth Stat, Chongqing, Peoples R China; [Xiao, Chenghan; Liu, Zhenmi] Sichuan Univ, West China Sch Publ Hlth, Dept Maternal Child & Adolescent Hlth, Chengdu, Peoples R China; [Zhang, Ling] Sichuan Univ, Sch Polymer Sci & Engn, Dept Iatr Polymer Mat & Artificial Apparat, Chengdu, Peoples R China; [Yao, Yuqin] Sichuan Univ, West China Sch Publ Hlth, Dept Occupat & Environm Hlth, Chengdu, Peoples R China; [Jiang, Xia] Sichuan Univ, West China Sch Publ Hlth, Dept Nutr & Food Hyg, Chengdu, Peoples R China; [Jiang, Xia] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden; [Jiang, Xia; Zhang, Ben] Sichuan Univ, West China Sch Publ Hlth, Chengdu, Sichuan, Peoples R China"

通信作者："Jiang, X; Zhang, B (通讯作者)，Sichuan Univ, West China Hosp 4, Chengdu, Sichuan, Peoples R China.; Jiang, X; Zhang, B (通讯作者)，Sichuan Univ, West China Sch Publ Hlth, Chengdu, Sichuan, Peoples R China."

来源：INTERNATIONAL JOURNAL OF CANCER

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000974816400001

JCR分区：Q1

影响因子：5.7

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：ABO blood group; association; cancer; comparison; ethnicity

摘要："To comprehensively evaluate the etiological role of ABO blood group in human cancer, we conducted a large-scale meta-analysis of 127 publications totaling 20 million participants including 231 737 patients of 20 cancers, supplemented by genetic evidence. Effects of A, AB and B groups on cancer risk were investigated by respectively comparing with O group and their combined counterparts, and subgroup analysis by ethnicity was conducted for O-referent models. For cancer categories, A group increased risk of cancers of oral cavity and nasopharynx, digestive and female genital organs, while both AB and B groups showed associations with only digestive cancers. For individual cancers, A group significantly increased the risk of nine cancers including oral cavity (OR = 1.17, P = .013), stomach (OR = 1.19, P = 3.90 x 10(-15)), pancreas (OR = 1.33, P = 9.89 x 10(-33)), colorectum (OR = 1.09, P = .001), liver (OR = 1.23, P = .011), ovary (OR = 1.13, P = .001), cervix (OR = 1.17, P = .025), bladder (OR = 1.12, P = .025) and breast (OR = 1.06, P = .043). AB group showed associations with only three cancers: stomach (OR = 1.10, P = .007), pancreas (OR = 1.21, P = .001) and ovary (OR = 1.28, P = .006). B group, except for shared associations with A group on pancreas (OR = 1.20, P = 2.27 x 10(-5)) and cervix cancers (OR = 1.13, P = .011), had two distinct associations with esophagus (OR = 1.17, P = .002) and nonmelanoma skin cancers (OR = 0.96, P = .017). Ethnicity-specific analyses revealed the notable effects of non-O groups on pancreatic cancer both in Caucasians and Asians. In genetic analysis, four SNPs were associated with the risk of pancreatic cancer, with rs505922 corresponding to O group showing the strongest protective effect (P = 1.16 x 10(-23)). Our study provides comprehensive evidence of ABO blood group associated with cancers and highlighted its carcinogenic role."

基金机构："Data Center of Management Science, National Natural Science Foundation of China -Peking University [81673255, 81874283, U22A20359]; National Key R&D Program of China [2022YFC3600600, 2022YFC3600604]; Promotion Plan for Basic Medical Sciences and the Development Plan for Cutting-Edge Disciplines, Cutting -Edge Disciplines, Sichuan University; Recruitment Program for Young Professionals of China"

基金资助正文："Data Center of Management Science, National Natural Science Foundation of China -Peking University, Grant/Award Numbers: 81673255, 81874283, U22A20359; The National Key R&D Program of China, Grant/Award Numbers: 2022YFC3600600, 2022YFC3600604; The Promotion Plan for Basic Medical Sciences and the Development Plan for Cutting-Edge Disciplines, Cutting -Edge Disciplines, Sichuan University; The Recruitment Program for Young Professionals of China"