Functional and morphological evaluation of the meibomian glands and ocular surface assessment at high altitude

作者全名："Li, Zhouyu; Wan, Wenjuan; Ji, Yan; Zheng, Shijie; Hu, Ke"

作者地址："[Li, Zhouyu; Wan, Wenjuan; Ji, Yan; Zheng, Shijie; Hu, Ke] Chongqing Med Univ, Affiliated Hosp 1, Chongqing Eye Inst, Chongqing Key Lab Ophthalmol, Chongqing, Peoples R China; [Hu, Ke] Chongqing Med Univ, Affiliated Hosp 1, Chongqing Eye Inst, Chongqing Key Lab Ophthalmol, Chongqing 400016, Peoples R China"

通信作者："Hu, K (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Chongqing Eye Inst, Chongqing Key Lab Ophthalmol, Chongqing 400016, Peoples R China."

来源：INDIAN JOURNAL OF OPHTHALMOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000975413400059

JCR分区：Q2

影响因子：2.1

年份：2023

卷号：71

期号：4

开始页：1483

结束页：1487

文献类型：Article

关键词：Dry eye disease; high altitude; meibomian glands; ocular surface

摘要："Purpose: To compare the function and morphology of the meibomian glands and the ocular surface of individuals from highland and lowland. Methods: This was a randomized controlled trial. The study was performed with 104 individuals (51 individuals from the highland and 53 individuals from the lowland). Detailed eye examinations comprising tear meniscus height, lipid layer grading, non-invasive Keratograph tear breakup time (NIKBUT), and scoring of the meibomian glands from the upper and lower eyelids of the individuals were performed by Keratograph 5M (OCULUS, Wetzlar, Germany). Symptoms related to dry eye disease were assessed using the Ocular Surface Disease Index (OSDI). Results: In the highland group, tear meniscus height was lower (P = 0.024), lipid layer grade, as well as all the meiboscores were higher (P < 0.05) than that in the lowland group. The OSDI (P = 0.018) and the percentage of dry eye disease were also higher as compared to that of the lowland group (P = 0.032). The first NIKBUT and average NIKBUT did not differ significantly between groups. The frequency of plugged meibomian gland orifices was greater in the lowland group compared to the highland group (P = 0.036). Conclusion: It was observed that dry eye disease was more common in the highland group. The morphological changes of meibomian gland dropout were significant in highlanders as demonstrated objectively with Keratograph 5M. Our study may raise a concern for environmental influences on ocular surface changes."

基金机构："National Natural Science Foundation of China [81870650, 82000883, 81970832, 81900885]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (grant numbers 81870650, 81970832, 82000883, and 81900885)."