Risk Factors to Predict Post-Operative Organ/Space Infection After Appendectomy in the Pediatric Population: A Retrospective Case Control Analysis

作者全名："Zhong, Yutong; Xia, Bingshan; Liu, Qianyang; Yan, Chengwei; Zeng, Defeng; Chen, Gongli; Guo, Chunbao"

作者地址："[Zhong, Yutong; Xia, Bingshan; Liu, Qianyang; Zeng, Defeng; Chen, Gongli; Guo, Chunbao] Chongqing Med Univ, Womens & Childrens Hosp, Dept Pediat, Chongqing, Peoples R China; [Zhong, Yutong] Chongqing Med Univ, Childrens Hosp, Dept Pediat, Chongqing, Peoples R China; [Zhong, Yutong; Xia, Bingshan; Liu, Qianyang; Zeng, Defeng; Chen, Gongli; Guo, Chunbao] Chongqing Hlth Ctr Women & Children, Dept Gynecol & Obstet, Chongqing, Peoples R China; [Yan, Chengwei] Chongqing Univ, Dept Pediat Gen Surg, Gorges Hosp 3, Chongqing, Peoples R China; [Guo, Chunbao] Chongqing Med Univ, Chongqing Maternal & Child Hlth Hosp, Dept Pediat Gen Surg, Chongqing, Peoples R China; [Guo, Chunbao] Chongqing Med Univ, Women & Childrens Hosp, Dept Pediat, 120 Longshan Rd, Chongqing 401147, Peoples R China; [Chen, Gongli] Chongqing Med Univ, Women & Childrens Hosp, Dept Gynecol & Obstet, 120 Longshan Rd, Chongqing 401147, Peoples R China"

通信作者："Guo, CB (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Dept Pediat, 120 Longshan Rd, Chongqing 401147, Peoples R China.; Chen, GL (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Dept Gynecol & Obstet, 120 Longshan Rd, Chongqing 401147, Peoples R China."

来源：SURGICAL INFECTIONS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000977876300001

JCR分区：Q3

影响因子：1.4

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：appendiceal abscess; laparoscopic appendectomy; pan-peritonitis; post-operative organ; space infection (OSI); risk factors

摘要："Background: Post-operative organ/space infection (OSI) is associated with prolonged hospital stay or re-admission. Here, we explore the predictors for OSI in pediatric patients after appendectomy.Patients and Methods: Among post-appendectomy pateints, the OSI was reviewed. A multicenter case control study was conducted to explore the risk factors for OSI among pediatric patients with appendicitis after appendectomy between January 2009 and December 2019. The potential risk factors associated with OSI were explored using multivariable logistic regression methods.Results: In the current cohort, 723 patients fulfilled the OSI criteria. According to multivariable logistic regression analysis, the occurrence of OSI was associated with complicated appendicitis (odds ratio [OR], 1.82; 95% confidence interval [CI], 1.03-3.686; p = 0.016), the lower the level of pre-operative lymphocyte-C-reactive protein (LCR; OR, 14.42; 95% CI, 1.57-73.26; p < 0.001), pan-peritonitis (OR, 4.36; 95% CI, 1.34-21.66; p = 0.006), systemic inflammatory response syndrome (SIRS; OR, 8.22; 95% CI, 1.84-49.63; p < 0.001), and abscess presentation (OR, 11.32; 95% CI, 2.03-61.86; p < 0.001). The receiver operating characteristic (ROC) curve evaluation further confirmed the relatively high accuracy of the above factors to predict OSI.Conclusions: The identified potential risk factors in the current research can be used for OSI identification in patients after appendectomy. Recognition of the risk factors may allow the choice of the treatment process more reasonably."

基金机构："Key Project of the Chongqing Natural Science Foundation [2008BA0021, cstc2012jjA0155]; Chongqing Health Planning Commission of Research Fund [2016MSXM044]"

基金资助正文："This study was supported by grants from the Key Project of the Chongqing Natural Science Foundation (CSTC, 2008BA0021, cstc2012jjA0155) for collection, analysis, and interpretation of data and Chongqing Health Planning Commission of Research Fund (No: 2016MSXM044) in writing the manuscript. The funding agency paid for the scholarships of the students involved in the research."