Efficacy of Children Neuropsychological and Behavioral Scale in Screening for Autism Spectrum Disorders through a Combination of Developmental Surveillance

作者全名："Li, Jin-hui; Zhao, Jin-zhu; Hua, Li; Hu, Xiao-lin; Tang, Li-na; Yang, Ting; He, Tian-yi; Hu, Chen; Yu, Xiao-qun; Xiong, Ting-ting; Wu, Dan-dan; Hao, Yan"

作者地址："[Li, Jin-hui; Zhao, Jin-zhu; Hua, Li; Hu, Xiao-lin; Tang, Li-na; He, Tian-yi; Hu, Chen; Xiong, Ting-ting; Wu, Dan-dan; Hao, Yan] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Div Child Healthcare,Dept Pediat, Wuhan 430030, Peoples R China; [Yang, Ting] Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Childhood Nutr & Hlth, Chongqing 404100, Peoples R China; [Yu, Xiao-qun] Future Hlth Biotechnol, 61000, Chengdu, Peoples R China"

通信作者："Hao, Y (通讯作者)，Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Div Child Healthcare,Dept Pediat, Wuhan 430030, Peoples R China."

来源：CURRENT MEDICAL SCIENCE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000978536000001

JCR分区：Q3

影响因子：2

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：autism spectrum disorder; Children Neuropsychological and Behavioral Scale; screening for autism spectrum disorder; developmental assessment

摘要："ObjectiveThis study aimed to explore the clinical value of Children Neuropsychological and Behavioral Scale-Revision 2016 (CNBS-R2016) for Autism Spectrum Disorder (ASD) screening in the presence of developmental surveillance.MethodsAll participants were evaluated by the CNBS-R2016 and Gesell Developmental Schedules (GDS). Spearman's correlation coefficients and Kappa values were obtained. Taking GDS as a reference assessment, the performance of the CNBS-R2016 for detecting the developmental delays of children with ASD was analyzed with receiver operating characteristic (ROC) curves. The efficacy of the CNBS-R2016 to screen for ASD was explored by comparing Communication Warning Behavior with Autism Diagnostic Observation Schedule, Second Edition (ADOS-2).ResultsIn total, 150 children aged 12-42 months with ASD were enrolled. The developmental quotients of the CNBS-R2016 were correlated with those of the GDS (r=0.62-0.94). The CNBS-R2016 and GDS had good diagnostic agreement for developmental delays (Kappa=0.73-0.89), except for Fine Motor. There was a significant difference between the proportions of Fine Motor, delays detected by the CNBS-R2016 and GDS (86.0% vs. 77.3%). With GDS as a standard, the areas under the ROC curves of the CNBS-R2016 were above 0.95 for all the domains except Fine Motor, which was 0.70. In addition, the positive rate of ASD was 100.0% and 93.5% when the cut-off points of 7 and 12 in the Communication Warning Behavior subscale were used, respectively.ConclusionThe CNBS-R2016 performed well in developmental assessment and screening for children with ASD, especially by Communication Warning Behaviors subscale. Therefore, the CNBS-R2016 is worthy of clinical application in children with ASD in China."

基金机构：　

基金资助正文：